Evidence map›Paper›PMID 37316826›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2023

Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse.

Marco Guglielmo, Dimitri Arangalage, Marco Augusto Bonino, Gianmarco Angelini, Michela Bonanni, Gianluca Pontone, Patrizio Pascale, Laura Anna Leo, Francesco Faletra, Jurg Schwitter and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Regional strain patterns in patients with mitral valve prolapse.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 4 countries.

Marco GuglielmoDivision of Heart and Lungs, Department of Cardiology, Utrecht University, Utrecht University Medical Center, Utrecht, The Netherlands.
Dimitri ArangalageCardiology Department, AP-HP, Bichat Hospital and Université de Paris, Paris, France.
Marco Augusto BoninoDepartment of Surgery, Hopital Universitaire Genève, Geneva, Switzerland.
Gianmarco AngeliniCardiology Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Policlinico of Bari, University Hospital, Bari, Italy.
Michela BonanniDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Gianluca PontoneCentro Cardiologico Monzino IRCCS, Milan, Italy.
Patrizio PascaleDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete, 48, 6900, Lugano, Switzerland.
Laura Anna LeoDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete, 48, 6900, Lugano, Switzerland.
Francesco FaletraDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete, 48, 6900, Lugano, Switzerland.
Jurg SchwitterDepartment of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Giovanni PedrazziniDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete, 48, 6900, Lugano, Switzerland.
Pierre MonneyDepartment of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Anna Giulia PavonDivision of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete, 48, 6900, Lugano, Switzerland. annagiulia.pavon@eoc.ch.ORCID 0000-0002-8001-1476
Ente Ospedaliero Cantonale · CHUniversity of Lausanne · CHCentro Cardiologico Monzino · ITHôpital Beau-Séjour · CHUniversité Paris Cité · FRUniversity of Bari Aldo Moro · ITUniversity of Rome Tor Vergata · ITUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe identification of patients with mitral valve prolapse (MVP) presenting high arrhythmic risk remains challenging. Cardiovascular Magnetic Resonance (CMR) feature tracking (FT) may improve risk stratification. We analyzed the role of CMR-FT parameters in relation to the incidence of complex ventricular arrhythmias (cVA) in patients with MVP and mitral annular disjunction (MAD).

methods42 patients with MVP and MAD who underwent 1.5 T CMR were classified as MAD-cVA (n = 23, 55%) in case of cVA diagnosed on a 24-h Holter monitoring and as MAD-noVA in the absence of cVA (n = 19, 45%). MAD length, late gadolinium enhancement (LGE), basal segments myocardial extracellular volume (ECV) and CMR-FT were assessed.

resultsLGE was more frequent in the MAD-cVA group in comparison with the MAD-noVA group (78% vs 42%, p = 0.002) while no difference was observed in terms of basal ECV. Global longitudinal strain (GLS) was reduced in MAD-cVA compared to MAD-noVA (- 18.2% ± 4.6% vs - 25.1% ± 3.1%, p = 0.004) as well as global circumferential strain (GCS) at the mid-ventricular level (- 17.5% ± 4.7% vs - 21.6% ± 3.1%, p = 0.041). Univariate analysis identified as predictors of the incidence of cVA: GCS, circumferential strain (CS) in the basal and mid infero-lateral wall, GLS, regional longitudinal strain (LS) in the basal and mid-ventricular inferolateral wall. Reduced GLS [Odd ratio (OR):1.56 (confidence interval (CI) 95%: 1.45-2.47; p < 0.001)] and regional LS in the basal inferolateral wall [OR: 1.62 (CI 95%: 1.22-2.13; p < 0.001)] remained independent prognostic factors in multivariate analysis.

conclusionIn patients with MVP and MAD, CMR-FT parameters are correlated with the incidence of cVA and may be of interest in arrhythmic risk stratification.

Indexed as

Mitral Valve ProlapseContrast MediaGadoliniumHumansMagnetic Resonance SpectroscopyPredictive Value of TestsContrast MediaGadoliniumCardiovascular magnetic resonanceInterstitial fibrosisMitral annular disjunctionMitral valve prolapseStrain

Identifiers

PMID37316826
PMCPMC10268415
OpenAlexW4380686847

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.