ArticleScientific reports2023
Sex difference in the association of the triglyceride glucose index with obstructive coronary artery disease.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Sex-specific associations of the triglyceride-glucose index with systemic inflammation and arterial stiffness in adults with normal glucose and triglyceride levels.Atherosclerosis plus · 2026Article
- Comparative evaluation of nine insulin resistance indices for 10-year coronary artery disease risk prediction in non-diabetic adults.Scientific reports · 2026Article
- Development and validation of machine learning-based risk prediction models of coronary artery disease using Porphyromonas gingivalis concentration.BMC oral health · 2026Article
- Interaction between triglyceride-glucose-body mass index and age in coronary artery stenosis severity: a sex-stratified exploratory analysis.BMC cardiovascular disorders · 2025Article
- The Role of Gender in the Relationship Between Waist-to-Hip Ratio, Triglyceride-Glucose Index, and Insulin Resistance in Korean Children.Healthcare (Basel, Switzerland) · 2025Article
- To study the role of triglyceride glucose index (TyG Index) as a novel biomarker in patients of type 2 diabetes mellitus (T2DM) developing acute coronary syndrome (ACS).Journal of family medicine and primary care · 2025Article
- Exosomal non-coding RNAs: key molecules in the diagnosis and treatment of coronary artery disease.PeerJ · 2025Review
- Association between shift work and insulin resistance in women: Implications for metabolic health.PloS one · 2025Article
- Advanced Cardiac Imaging and Women's Chest Pain: A Question of Gender.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) is associated with cardiovascular disease in non-diabetic patients. The triglyceride-glucose (TyG) index, incorporating serum glucose and insulin concentrations, is a surrogate insulin resistance marker. We investigated its association with obstructive coronary artery disease (CAD) and sex differences therein. Patients with stable angina pectoris requiring invasive coronary angiography between January 2010 and December 2018 were enrolled. They were divided into two groups according to TyG index. Two interventional cardiologists diagnosed obstructive CAD by angiography review. Demographic characteristics and clinical outcomes were compared between groups. Relative to lower index, patients with higher (≥ 8.60) TyG index had higher BMIs and more prevalent hypertension, diabetes, and elevated lipid profiles [total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), fasting plasma glucose (FPG)]. Higher TyG index increased women's obstructive CAD risk after multivariate adjustment (adjusted odds ratio (aOR) 2.15, 95% confidence interval (95% CI) 1.08-4.26, p = 0.02) in non-diabetic populations compared with men. No sex difference was found for diabetic patients. Higher TyG index significantly increased the obstructive CAD risk, overall and for non-diabetic women. Larger-scale studies are needed to confirm our findings.
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