Observational studyPediatric nephrology (Berlin, Germany)2023
Clinical course and management of children with IgA vasculitis with nephritis.
Observational study in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Pooled it
- Clinical, laboratory, and pathological correlates of crescent formation in biopsy-proven pediatric IgA vasculitis nephritis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Association of the inflammation indicators with multiple system involved of immunoglobulin A vasculitis in children.Frontiers in pediatrics · 2026Article
- Recurrent immunoglobulin A vasculitis in children and adolescents: prevalence and associated risk factors.Clinical and experimental pediatrics · 2026Article
- Article
- Risk Factors of Histopathological Crescent Formation in Pediatric IgA Vasculitis Nephritis.Medicina (Kaunas, Lithuania) · 2025Article
- Correlation between the course of kidney injury and clinicopathology and prognosis of children with Henoch-Schönlein purpura nephritis.International urology and nephrology · 2025Article
- IgA vasculitis induced by tumor necrosis factor-α antagonists: clinical features, diagnosis and management.Archives of dermatological research · 2025Article
- The IgA Vasculitis Study: the evolution of a cross-sectional cohort into a trial-ready cohort.Rheumatology advances in practice · 2025Article
- Renal disease in pediatric rheumatology.Current opinion in rheumatology · 2024Review
- An Investigation of the Relationship between Henoch-Schönlein Purpura and Viral Infection in Korea Using the Health Insurance Database.Journal of clinical medicine · 2024Article
- External validation of the pediatric International IgA Nephropathy Prediction Tool in a central China cohort.Clinical and experimental nephrology · 2024Article
- The Preserving Kidney Function in Children With CKD (PRESERVE) Study: Rationale, Design, and Methods.Kidney medicine · 2023Article
Corrections and comments
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Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundIgA vasculitis is the most common vasculitis in children and is often complicated by acute nephritis (IgAVN). Risk of chronic kidney disease (CKD) among children with IgAVN remains unknown. This study aimed to describe the clinical management and kidney outcomes in a large cohort of children with IgAVN.
methodsThis observational cohort study used the PEDSnet database to identify children diagnosed with IgAV between January 1, 2009, and February 29, 2020. Demographic and clinical characteristics were compared among children with and without kidney involvement. For children followed by nephrology, clinical course, and management patterns were described. Patients were divided into four categories based on treatment: observation, renin-angiotensin-aldosterone system (RAAS) blockade, corticosteroids, and other immunosuppression, and outcomes were compared among these groups.
resultsA total of 6802 children had a diagnosis of IgAV, of whom 1139 (16.7%) were followed by nephrology for at least 2 visits over a median follow-up period of 1.7 years [0.4,4.2]. Conservative management was the most predominant practice pattern, consisting of observation in 57% and RAAS blockade in 6%. Steroid monotherapy was used in 29% and other immunosuppression regimens in 8%. Children receiving immunosuppression had higher rates of proteinuria and hypertension compared to those managed with observation (p < 0.001). At the end of follow-up, 2.6 and 0.5% developed CKD and kidney failure, respectively.
conclusionsKidney outcomes over a limited follow-up period were favorable in a large cohort of children with IgAV. Immunosuppressive medications were used in those with more severe presentations and may have contributed to improved outcomes. A higher resolution version of the Graphical abstract is available as Supplementary information.
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