Evidence map›Paper›PMID 37316668›Full record

ArticleNature2023

Mitotic tethering enables inheritance of shattered micronuclear chromosomes.

Prasad Trivedi, Christopher D Steele, Franco K C Au, Ludmil B Alexandrov, Don W Cleveland

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Targeting extrachromosomal DNA in human cancers.Nature reviews. Drug discovery · 2026
    Review
  6. Article
  7. Micronuclei: origins, assays, mechanisms, diseases and treatments.Signal transduction and targeted therapy · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Chromothripsis in cancer.Nature reviews. Cancer · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Prasad TrivediLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Christopher D SteeleDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.
Franco K C AuDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.
Don W ClevelandLudwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. dcleveland@health.ucsd.edu.ORCID 0000-0002-1934-3682
University of California San Diego · USUC San Diego Health System · US

Funding

Mechanisms of chromosome segregation, aneuploidy, and tumorigenesisR35GM122476 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Don W Cleveland · 2017 to 2026
$9.0M
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4M
Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet RadiationR01ES030993 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HUDSON, LAURIE G, LIU, KE JIAN · 2020 to 2024
$2.5M
Comprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2M
NCI NIH HHS R01 CA269919NIEHS NIH HHS R01 ES030993NIEHS NIH HHS R01 ES032547NIGMS NIH HHS R35 GM122476
6 · The paper itself

Abstract

Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome(s)

Indexed as

Cell NucleusChromosome SegregationChromosomes, HumanChromothripsisMitosisAdaptor Proteins, Signal TransducingAutoantigensCarrier ProteinsCell Cycle ProteinsChromatinDNA-Binding ProteinsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsNeoplasmsNuclear ProteinsAdaptor Proteins, Signal TransducingAutoantigensCarrier ProteinsCell Cycle ProteinsChromatinCIP2A protein, humanDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsMDC1 protein, humanMembrane ProteinsNuclear ProteinsTOPBP1 protein, human

Identifiers

PMID37316668
PMCPMC10424572
OpenAlexW4380625325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.