Evidence map›Paper›PMID 37316571›Full record

ArticleScientific reports2023

Aquaporin-4 expression and modulation in a rat model of post-traumatic syringomyelia.

Joel A Berliner, Magdalena A Lam, Elmira Najafi, Sarah J Hemley, Lynne E Bilston, Marcus A Stoodley

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Joel A BerlinerFaculty of Medicine, Health and Human Sciences, Macquarie University, 2 Technology Place, Sydney, NSW, 2109, Australia. joel.berliner@mq.edu.au.
Magdalena A LamThe ANZAC Research Institute, Concord Repatriation General Hospital, Gate 3, Hospital Road, Sydney, NSW, 2139, Australia.
Elmira NajafiFaculty of Medicine, Health and Human Sciences, Macquarie University, 2 Technology Place, Sydney, NSW, 2109, Australia.
Sarah J HemleyFaculty of Medicine, Health and Human Sciences, Macquarie University, 2 Technology Place, Sydney, NSW, 2109, Australia.
Lynne E BilstonNeuroscience Research Australia, Margarete Ainsworth Building, 139 Barker Street, Sydney, NSW, 2031, Australia.
Marcus A StoodleyFaculty of Medicine, Health and Human Sciences, Macquarie University, 2 Technology Place, Sydney, NSW, 2109, Australia.
Macquarie University · AUConcord Repatriation General Hospital · AUNeuroscience Research Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquaporin-4 (AQP4) has been implicated in post-traumatic syringomyelia (PTS), a disease characterised by the formation of fluid-filled cysts in the spinal cord. This study investigated the expression of AQP4 around a mature cyst (syrinx) and the effect of pharmacomodulation of AQP4 on syrinx size. PTS was induced in male Sprague-Dawley rats by computerized spinal cord impact and subarachnoid kaolin injection. Immunofluorescence of AQP4 was carried out on mature syrinx tissue 12 weeks post-surgery. Increased AQP4 expression corresponded to larger, multiloculated cysts (R

Indexed as

CystsSyringomyeliaAnimalsAquaporin 4MaleRatsRats, Sprague-DawleyAquaporin 4

Identifiers

PMID37316571
PMCPMC10267129
OpenAlexW4380627767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.