Evidence map›Paper›PMID 37316540›Full record

ArticleScientific reports2023

Normal human craniofacial growth and development from 0 to 4 years.

Ce Liang, Antonio Profico, Costantino Buzi, Roman H Khonsari, David Johnson, Paul O'Higgins, Mehran Moazen

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. A Unique Case of Pure Bilateral Lambdoid Craniosynostosis and Progression to Mercedes-Benz Syndrome Following Spring Cranioplasty.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ce LiangDepartment of Mechanical Engineering, University College London, London, UK.
Antonio ProficoDepartment of Biology, University of Pisa, Pisa, Italy.
Costantino BuziInstitut Català de Paleoecologia Humana i Evolució Social (IPHES-CERCA), Tarragona, Spain.
Roman H KhonsariDepartment of Maxillofacial Surgery and Plastic Surgery, Necker - Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
David JohnsonOxford Craniofacial Unit, Oxford University Hospital, Oxford, UK.
Paul O'HigginsPalaeoHub, Department of Archaeology, University of York, York, UK.
Mehran MoazenDepartment of Mechanical Engineering, University College London, London, UK. M.Moazen@ucl.ac.uk.

Funding

Marie Curie 101025525
6 · The paper itself

Abstract

Knowledge of human craniofacial growth (increase in size) and development (change in shape) is important in the clinical treatment of a range of conditions that affects it. This study uses an extensive collection of clinical CT scans to investigate craniofacial growth and development over the first 48 months of life, detail how the cranium changes in form (size and shape) in each sex and how these changes are associated with the growth and development of various soft tissues such as the brain, eyes and tongue and the expansion of the nasal cavity. This is achieved through multivariate analyses of cranial form based on 3D landmarks and semi-landmarks and by analyses of linear dimensions, and cranial volumes. The results highlight accelerations and decelerations in cranial form changes throughout early childhood. They show that from 0 to 12 months, the cranium undergoes greater changes in form than from 12 to 48 months. However, in terms of the development of overall cranial shape, there is no significant sexual dimorphism in the age range considered in this study. In consequence a single model of human craniofacial growth and development is presented for future studies to examine the physio-mechanical interactions of the craniofacial growth.

Indexed as

AccelerationSkullBrainChild, PreschoolEyeGrowth and DevelopmentHumans

Identifiers

PMID37316540
PMCPMC10267183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.