Evidence map›Paper›PMID 37316507›Full record

ArticleScientific reports2023

Microstructural brain tissue changes contribute to cognitive and mood deficits in adults with type 2 diabetes mellitus.

Bhaswati Roy, Sarah E Choi, Matthew J Freeby, Rajesh Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bhaswati RoyDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 56-141 CHS, 10833 Le Conte Ave, Los Angeles, CA, 90095-1763, USA.
Sarah E ChoiUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Matthew J FreebyDepartment of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
Rajesh KumarDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 56-141 CHS, 10833 Le Conte Ave, Los Angeles, CA, 90095-1763, USA. rkumar@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Relationships Between Brain Tissue Integrity and Self-Care Abilities in Adults with Type 2 Diabetes-Administrative SupplementR01NR017190 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOI, SARAH E, KUMAR, RAJESH · 2018 to 2021
$2.5M
NINR NIH HHS R01 NR017190
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) patients show brain tissue changes in mood and cognitive regulatory sites, but the nature and extent of tissue injury and their associations with symptoms are unclear. Our aim was to examine brain tissue damage in T2DM over controls using mean diffusivity (MD) computed from diffusion tensor imaging (DTI), and assess correlations with mood and cognitive symptoms in T2DM. We collected DTI series (MRI), mood, and cognitive data, from 169 subjects (68 T2DM and 101 controls). Whole-brain MD-maps were calculated, normalized, smoothed, and compared between groups, as well as correlated with mood and cognition scores in T2DM subjects. Type 2 diabetes patients showed altered cognitive and mood functions over control subjects. Multiple brain sites in T2DM patients showed elevated MD values, indicating chronic tissue changes, including the cerebellum, insula, and frontal and prefrontal cortices, cingulate, and lingual gyrus. Associations between MD values and mood and cognition scores appeared in brain sites mediating these functions. Type 2 diabetes patients show predominantly chronic brain tissue changes in areas mediating mood and cognition functions, and tissue changes from those regions correlate with mood and cognitive symptoms suggesting that the microstructural brain changes may account for the observed functional deficits.

Indexed as

Brain InjuriesDiabetes Mellitus, Type 2AdultBrainCognitionDiffusion Tensor ImagingHumans

Identifiers

PMID37316507
PMCPMC10267112
OpenAlexW4380729876

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.