ArticleMolecular pharmacology2023
Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABA
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Article in Molecular pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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1 citing paper in PubMed, 2 citations in OpenAlex.
- Central and peripheral analgesic active components of triterpenoid saponins fromFrontiers in pharmacology · 2023Article
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Authors and funding
10 authors at 4 institutions in 4 countries.
Hugo R AriasDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.) hugo.arias@okstate.edu.
Spencer R PierceDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Allison L GermannDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Sophia Q XuDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Marcelo O OrtellsDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Seiji SakamotoDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Dina ManettiDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Maria Novella RomanelliDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Itaru HamachiDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Gustav AkkDepartment of Pharmacology and Physiology, Oklahoma State University College of Osteopathic Medicine, Tahlequah, Oklahoma (H.R.A.); Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri (S.R.P., A.L.G., S.Q.X., G.A.); Facultad de Medicina, Universidad de Morón, Morón, and CONICET, Argentina (M.O.O.); Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan (S.S., I.H.); Department of Neurosciences, Psychology, Drug Research and Child Health Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Florence, Italy (D.M., M.N.R.); The Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St. Louis, Missouri (G.A.).
Kyoto University · JPUniversity of Florence · ITOklahoma State University Medical Center · USUniversidad de Morón · AR
Funding
GABAA receptors: function, physiology and involvement in anesthesiaR35GM140947 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2021 to 2025
$1.8MNIGMS NIH HHS R35 GM140947
Abstract
Acrylamide-derived compounds have been previously shown to act as modulators of members of the Cys-loop transmitter-gated ion channel family, including the mammalian GABA
Indexed as
AnestheticsNeurosteroidsAcrylamideAnimalsBinding SitesFuransMammalsMolecular Docking SimulationReceptors, GABA-ASteroidsAcrylamideAnestheticsFuransNeurosteroidsReceptors, GABA-ASteroids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.