Evidence map›Paper›PMID 37316269›Full record

ArticleInternal medicine (Tokyo, Japan)2024

Type 1 Cryoglobulinemic Vasculitis Due to Monoclonal Gammopathy of Undetermined Significance Successfully Treated by Bortezomib Plus Dexamethasone.

Ryo Kikuchi, Masahiro Onozawa, Jun Nagai, Satomi Okada, Yuta Hasegawa, Hiroyuki Ohigashi, Shintaro Mitamura, Taku Maeda, Emi Takakuwa, Yuichiro Fujieda and 4 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Ryo KikuchiDepartment of Hematology, Hokkaido University Hospital, Japan.
Masahiro OnozawaDepartment of Hematology, Hokkaido University Hospital, Japan.
Jun NagaiDepartment of Hematology, Hokkaido University Hospital, Japan.
Satomi OkadaDepartment of Hematology, Hokkaido University Hospital, Japan.
Yuta HasegawaDepartment of Hematology, Hokkaido University Hospital, Japan.
Hiroyuki OhigashiDepartment of Hematology, Hokkaido University Hospital, Japan.
Shintaro MitamuraDivision of Plastic Surgery, Hokkaido University Hospital, Japan.
Taku MaedaDivision of Plastic Surgery, Hokkaido University Hospital, Japan.
Emi TakakuwaDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Yuichiro FujiedaDepartment of Rheumatology and Nephrology, Hokkaido University Hospital, Japan.
Hideki GotoDepartment of Hematology, Hokkaido University Hospital, Japan.
Daigo HashimotoDepartment of Hematology, Hokkaido University Hospital, Japan.
Yoshihiro MatsunoDepartment of Surgical Pathology, Hokkaido University Hospital, Japan.
Takanori TeshimaDepartment of Hematology, Hokkaido University Hospital, Japan.
Hokkaido University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryoglobulins are immunoglobulins that precipitate in cold conditions. Type I cryoglobulinemic vasculitis is associated with hematological malignancies. We herein report a case of steroid-resistant type 1 cryoglobulinemic vasculitis associated with monoclonal gammopathy of undetermined significance (MGUS) in a 47-year-old woman. By immunofixation of cryoglobulin, we found that the main component of cryoglobulin was the M protein due to MGUS, so treatment of MGUS was needed. Bortezomib+dexamethasone therapy resulted in a rapid decrease in cryoglobulin and improvement in the symptoms of cryoglobulinemic vasculitis. In refractory type I cryoglobulinemic vasculitis, treatment of the underlying gammaglobulinopathy should be considered.

Indexed as

CryoglobulinemiaMonoclonal Gammopathy of Undetermined SignificanceParaproteinemiasVasculitisBortezomibCryoglobulinsDexamethasoneFemaleHumansMiddle AgedBortezomibCryoglobulinsDexamethasonebortezomibcryoglobulinMGUS

Identifiers

PMID37316269
PMCPMC10937136
OpenAlexW4380537656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.