Evidence map›Paper›PMID 37316256›Full record

ArticleBMJ mental health2023

Assessing violence risk in first-episode psychosis: external validation, updating and net benefit of a prediction tool (OxMIV).

Daniel Whiting, Sue Mallett, Belinda Lennox, Seena Fazel

Abstract read
In one paragraph

Article in BMJ mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Violence in schizophrenia: triangulating the evidence on perpetration risk.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel WhitingInstitute of Mental Health, University of Nottingham, Nottingham, UK daniel.whiting@nottingham.ac.uk.ORCID 0000-0001-5323-364X
Sue MallettCentre for Medical Imaging, University College London, London, UK.
Belinda LennoxDepartment of Psychiatry, University of Oxford, Oxford, UK.
Seena FazelDepartment of Psychiatry, University of Oxford, Oxford, UK.

Funding

Medical Research Council MR/J012939/1Medical Research Council MR/N019067/1Wellcome Trust 202836/Z/16/Z
6 · The paper itself

Abstract

backgroundViolence perpetration is a key outcome to prevent for an important subgroup of individuals presenting to mental health services, including early intervention in psychosis (EIP) services. Needs and risks are typically assessed without structured methods, which could facilitate consistency and accuracy. Prediction tools, such as OxMIV (Oxford Mental Illness and Violence tool), could provide a structured risk stratification approach, but require external validation in clinical settings.

objectivesWe aimed to validate and update OxMIV in first-episode psychosis and consider its benefit as a complement to clinical assessment.

methodsA retrospective cohort of individuals assessed in two UK EIP services was included. Electronic health records were used to extract predictors and risk judgements made by assessing clinicians. Outcome data involved police and healthcare records for violence perpetration in the 12 months post-assessment.

findingsOf 1145 individuals presenting to EIP services, 131 (11%) perpetrated violence during the 12 month follow-up. OxMIV showed good discrimination (area under the curve 0.75, 95% CI 0.71 to 0.80). Calibration-in-the-large was also good after updating the model constant. Using a 10% cut-off, sensitivity was 71% (95% CI 63% to 80%), specificity 66% (63% to 69%), positive predictive value 22% (19% to 24%) and negative predictive value 95% (93% to 96%). In contrast, clinical judgement sensitivity was 40% and specificity 89%. Decision curve analysis showed net benefit of OxMIV over comparison approaches.

conclusionsOxMIV performed well in this real-world validation, with improved sensitivity compared with unstructured assessments. CLINICAL IMPLICATIONS: Structured tools to assess violence risk, such as OxMIV, have potential in first-episode psychosis to support a stratified approach to allocating non-harmful interventions to individuals who may benefit from the largest absolute risk reduction.

Indexed as

Psychotic DisordersCalibrationClinical ReasoningHumansRetrospective StudiesViolenceAdult psychiatryForensic psychiatrySchizophrenia & psychotic disorders

Identifiers

PMID37316256
PMCPMC10335427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.