Evidence map›Paper›PMID 37316162›Full record

ArticleHeart (British Cardiac Society)2023

Left ventricular ejection fraction and long-term outcomes in women presenting with signs and symptoms of ischaemia.

Stephanie Wu, Janet Wei, Marie Lauzon, Nissi Suppogu, Sheryl F Kelsey, Steven E Reis, Leslee J Shaw, George Sopko, Eileen Handberg, Carl J Pepine and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart (British Cardiac Society), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000554 (Women's Ischemia Syndrome Evaluation), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000554 phase3completednot on this map

Women's Ischemia Syndrome Evaluation (WISE)

TypeinterventionalSponsorUniversity of PittsburghRan2001 to 2007ConditionsAngina Pectoris, Cardiovascular Diseases, Coronary Disease, Heart DiseasesArmsAngiography, MRI, Dobutamine-Stress Echocardiography, PET,, Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Stephanie WuCedars-Sinai Medical Center, Los Angeles, California, USA.
Janet WeiHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Marie LauzonCedars-Sinai Medical Center, Los Angeles, California, USA.
Nissi SuppoguCedars-Sinai Medical Center, Los Angeles, California, USA.
Sheryl F KelseyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Steven E ReisHeart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Leslee J ShawDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
George SopkoNational Heart Lung and Blood Institute, Bethesda, Maryland, USA.
Eileen HandbergCardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
Carl J PepineCardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Cedars-Sinai Medical Center Smidt Heart Institute, Los Angeles, California, USA Noel.BaireyMerz@cshs.org.ORCID 0000-0002-9933-5155
Cedars-Sinai Medical Center · USUniversity of Pittsburgh · USUniversity of Florida · USNational Heart Lung and Blood Institute · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2020 to 2024
$8.7M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Behavioral Medicine and Cardiovascular Research TrainingT32HL069751 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI KRANTZ, DAVID S. · 2003 to 2007
$1.2M
Cardiac Autonomic Function in WomenK23HL105787 · NHLBI · EMORY UNIVERSITY · PI MEHTA, PUJA KIRAN · 2012 to 2016
$813k
ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTERN01HV068163 · HV · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 1996 to 2001
$386k
ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTERN01HV068161 · HV · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROGERS, WILLIAM J · 1996 to 2000
$245k
Cardiovascular Events in Women's Ischemia Syndrome EvaluationR03AG032631 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F · 2008 to 2009
$137k
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTRN01HV068164 · HV · ALLEGHENY-SINGER RESEARCH INSTITUTE · PI REICHEK, NATHANIEL · 1996 to 2001
–
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHS M01 RR000425NHLBI NIH HHS K23 HL105787NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS R01 HL090957NHLBI NIH HHS R01 HL146158NHLBI NIH HHS T32 HL069751NIA NIH HHS R03 AG032631NIA NIH HHS U54 AG065141
6 · The paper itself

Abstract

backgroundAlthough women are known to have a relatively higher left ventricular ejection fraction (LVEF) compared with men, a sex-neutral LVEF threshold continues to be used for clinical management. We sought to investigate the relationship among high (>65%), normal (55%-65%) and low (<55%) LVEF and long-term all-cause mortality and major adverse cardiovascular events (MACEs) in women presenting with suspected myocardial ischaemia.

methodsA total of 734 women from the Women's Ischemia Syndrome Evaluation (WISE) were analysed. LVEF was calculated by invasive left ventriculography. The relationship between baseline characteristics, LVEF and outcomes was evaluated. A multivariable Cox regression model was used to assess the association of LVEF with outcomes, after adjusting for known risk factors.

resultsLow LVEF was associated with higher rates of mortality and MACE compared with normal and high LVEF (p<0.0001). Normal LVEF was associated with higher mortality (p=0.047) and rate of myocardial infarctions (MIs) compared with high LVEF (p=0.03). Low LVEF remained a significant predictor of mortality compared with high LVEF (p=0.013) in a multivariable regression model and normal compared with high LVEF trended towards higher mortality (p=0.16).

conclusionAmong women with suspected ischaemia, women with LVEF above the defined normal threshold (>65%) had lower rates of all-cause mortality and non-fatal MI. Further investigation is needed to determine the optimal LVEF in women. TRIAL REGISTRATION NUMBER: NCT00000554.

Indexed as

Coronary Artery DiseaseMyocardial InfarctionFemaleHumansIschemiaMalePrognosisStroke VolumeVentricular Function, LeftOutcome Assessment, Health Care

Identifiers

PMID37316162
PMCPMC10592103
OpenAlexW4380608049

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.