Evidence map›Paper›PMID 37315949›Full record

ArticleStatistics in medicine2023

Relative sparsity for medical decision problems.

Samuel J Weisenthal, Sally W Thurston, Ashkan Ertefaie

Abstract read
In one paragraph

Article in Statistics in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samuel J WeisenthalDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York.ORCID 0000-0001-7921-1836
Sally W ThurstonDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York.
Ashkan ErtefaieDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York.ORCID 0000-0003-2611-9512

Funding

University of Rochester Mentoring Environment: Nurturing Training Opportunities in Research (UR-MENTOR)T32GM007356 · NIGMS · UNIVERSITY OF ROCHESTER · PI O'BANION, M. KERRY · 1985 to 2023
$15.1M
TRAINING IN ENVIRONMENTAL HEALTH SCIENCES BIOSTATISTICST32ES007271 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1992 to 2026
$3.9M
Analyzing Sequential, Multiple Assignment, Randomized Trials in the Presence of Partial ComplianceR01DA048764 · NIDA · UNIVERSITY OF ROCHESTER · PI ERTEFAIE, ASHKAN · 2019 to 2022
$1.6M
Advancing personalized medicine in PD using harmonized multi-site clinical dataR61NS120240 · NINDS · UNIVERSITY OF ROCHESTER · PI ERTEFAIE, ASHKAN, MCDERMOTT, MICHAEL P · 2020 to 2021
$1.1M
NIDA NIH HHS R01 DA048764NIEHS NIH HHS T32 ES007271NIEHS NIH HHS T32ES007271NIGMS NIH HHS T32 GM007356NIGMS NIH HHS T32GM007356NINDS NIH HHS R61 NS120240
6 · The paper itself

Abstract

Existing statistical methods can estimate a policy, or a mapping from covariates to decisions, which can then instruct decision makers (eg, whether to administer hypotension treatment based on covariates blood pressure and heart rate). There is great interest in using such data-driven policies in healthcare. However, it is often important to explain to the healthcare provider, and to the patient, how a new policy differs from the current standard of care. This end is facilitated if one can pinpoint the aspects of the policy (ie, the parameters for blood pressure and heart rate) that change when moving from the standard of care to the new, suggested policy. To this end, we adapt ideas from Trust Region Policy Optimization (TRPO). In our work, however, unlike in TRPO, the difference between the suggested policy and standard of care is required to be sparse, aiding with interpretability. This yields "relative sparsity," where, as a function of a tuning parameter,

Indexed as

Clinical Decision-MakingDelivery of Health CareHumanscausal inferenceindividualized medicinelassoreinforcement learningtrust region policy optimization

Identifiers

PMID37315949
PMCPMC10524900

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.