Evidence map›Paper›PMID 37315344›Full record

ArticleRedox biology2023

Vascular protection afforded by zinc supplementation in human coronary artery smooth muscle cells mediated by NRF2 signaling under hypoxia/reoxygenation.

Fan Yang, Matthew J Smith, Alexander Griffiths, Alexander Morrell, Sarah J Chapple, Richard C M Siow, Theodora Stewart, Wolfgang Maret, Giovanni E Mann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fan YangKing's British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK. Electronic address: fan.4.yang@kcl.ac.uk.
Matthew J SmithKing's British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
Alexander GriffithsLondon Metallomics Facility, Faculty of Life Sciences & Medicine, King's College London, UK.
Alexander MorrellLondon Metallomics Facility, Faculty of Life Sciences & Medicine, King's College London, UK.
Sarah J ChappleKing's British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
Richard C M SiowKing's British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK.
Theodora StewartResearch Management & Innovation Directorate (RMID), King's College London, UK.
Wolfgang MaretDepartments of Biochemistry and Nutritional Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences & Medicine, King's College London, UK.
Giovanni E MannKing's British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London, SE1 9NH, UK. Electronic address: giovanni.mann@kcl.ac.uk.
King's College London · GBLondon Metropolitan University · GB

Funding

Wellcome TrustWellcome Trust 202902/Z/16/Z
6 · The paper itself

Abstract

Zinc (Zn) has antioxidant, anti-inflammatory and anti-proliferative actions, with Zn dysregulation associated with coronary ischemia/reperfusion injury and smooth muscle cell dysfunction. As the majority of studies concerning Zn have been conducted under non-physiological hyperoxic conditions, we compare the effects of Zn chelation or supplementation on total intracellular Zn content, antioxidant NRF2 targeted gene transcription and hypoxia/reoxygenation-induced reactive oxygen species generation in human coronary artery smooth muscle cells (HCASMC) pre-adapted to hyperoxia (18 kPa O

Indexed as

Coronary VesselsHyperoxiaAntioxidantsDietary SupplementsGlutathioneHumansHypoxiaMyocytes, Smooth MuscleNF-E2-Related Factor 2RNA, MessengerSuperoxidesZincAntioxidantsGlutathioneNF-E2-Related Factor 2RNA, MessengerSuperoxidesZincCoronary artery smooth muscle cellsHyperoxiaHypoxiaHypoxia-reoxygenationMetallomicsMetallothioneinMetalsNRF2OxygenPhysiological normoxiaRedox statusZinc

Identifiers

PMID37315344
PMCPMC10363453
OpenAlexW4379741687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.