ArticleScience advances2023
Neuronal responses to omitted tones in the auditory brain: A neuronal correlate for predictive coding.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Frequency-Specific Neural Dynamics and Decoding of Hierarchical Auditory Sequences Revealed by Magnetoencephalography.Neuroscience bulletin · 2026Article
- Behavioral engagement and stimulus regularities coordinate auditory-prefrontal network activity.PLoS biology · 2026Article
- Signaling of salience and prediction errors by anterior insula neurons.Biochemical and biophysical research communications · 2026Article
- Ontology-constrained multi-LLM scoring of hypothesis support in the predictive processing literature.Research square · 2026Article
- Do auditory deviants evoke cortical state changes under anaesthesia? A proof-of-concept study.Experimental physiology · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- The predictive processing embodied in brain conditions: the role of precision.Frontiers in psychology · 2026Article
- The Somatosensory Mismatch Negativity.The European journal of neuroscience · 2025Review
- Duet model unifies diverse neuroscience experimental findings on predictive coding.bioRxiv : the preprint server for biology · 2025Article
- Auditory cortex neurons that encode negative prediction errors respond to omissions of sounds in a predictable sequence.PLoS biology · 2025Article
- Diversity of omission responses to visual images across brain-wide regions.Science advances · 2025Article
- Meeting Review of the '1st Azerbaijan Neuroscience School: Introduction'.Biology open · 2025Article
- Hierarchical Temporal Processing in the Primate Thalamocortical System: Insights from Nonlinguistic Structured Stimuli.Research (Washington, D.C.) · 2025Article
- Deviance detection and regularity sensitivity in dissociated neuronal cultures.Frontiers in neural circuits · 2025Article
- Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex.eLife · 2024Article
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7 authors.
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Abstract
Prediction provides key advantages for survival, and cognitive studies have demonstrated that the brain computes multilevel predictions. Evidence for predictions remains elusive at the neuronal level because of the complexity of separating neural activity into predictions and stimulus responses. We overcome this challenge by recording from single neurons from cortical and subcortical auditory regions in anesthetized and awake preparations, during unexpected stimulus omissions interspersed in a regular sequence of tones. We find a subset of neurons that responds reliably to omitted tones. In awake animals, omission responses are similar to anesthetized animals, but larger and more frequent, indicating that the arousal and attentional state levels affect the degree to which predictions are neuronally represented. Omission-sensitive neurons also responded to frequency deviants, with their omission responses getting emphasized in the awake state. Because omission responses occur in the absence of sensory input, they provide solid and empirical evidence for the implementation of a predictive process.
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