Evidence map›Paper›PMID 37315129›Full record

ArticleScience advances2023

Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications.

Meysam T Chorsi, Thinh T Le, Feng Lin, Tra Vinikoor, Ritopa Das, James F Stevens, Caitlyn Mundrane, Jinyoung Park, Khanh T M Tran, Yang Liu and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 133 citations in OpenAlex.

  1. Article
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  4. Article
  5. Article
  6. Scalable Manufacturing of Amino Acid-Based Piezoelectric Biocrystal Films.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Meysam T ChorsiDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-2633-9200
Thinh T LeDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-8180-2077
Feng LinDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-2700-3573
Tra VinikoorDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-7637-6296
Ritopa DasDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0001-7297-1998
James F StevensDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Caitlyn MundraneDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Jinyoung ParkDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-0943-3649
Khanh T M TranDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-5331-4068
Yang LiuDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-1655-828X
Jacob PfundDepartment of Physics, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0001-6745-489X
Rachel ThompsonDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Wu HeFlow Cytometry Facility, Center for Open Research Resources and Equipment, University of Connecticut, Storrs, CT 06269, USA.
Menka JainDepartment of Physics, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0002-2264-6895
M Daniela Morales-AcostaInstitute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-1145-9485
Osama R BilalDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-3803-5084
Kazem KazerounianDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0009-0004-7115-0070
Horea IliesDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0009-0000-1038-4536
Thanh D NguyenDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.ORCID 0000-0003-0813-4807
University of Connecticut · US

Funding

Novel Piezoelectric Amino-acid Ultrasound Transducer to Deliver Drugs Through the Blood Brain BarrierR01NS131310 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI Thanh Nguyen · 2023 to 2026
$1.8M
Biodegradable ultrasonic transducer for blood-brain drug-deliveryR21NS116095 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH, PACHTER, JOEL S · 2020 to 2020
$444k
NINDS NIH HHS R01 NS131310NINDS NIH HHS R21 NS116095
6 · The paper itself

Abstract

Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.

Indexed as

GlioblastomaNanofibersAmino AcidsAnimalsBrainGlycineMiceAmino AcidsGlycine

Identifiers

PMID37315129
PMCPMC10266740
OpenAlexW4380605979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.