Evidence map›Paper›PMID 37314891›Full record

ArticleJournal of the American Chemical Society2023

Axially Chiral Cannabinoids: Design, Synthesis, and Cannabinoid Receptor Affinity.

Sara E Kearney, Anghelo J Gangano, Daniel G Barrus, Kyle J Rehrauer, Terry-Elinor R Reid, Primali V Navaratne, Emily K Tracy, Adrian Roitberg, Ion Ghiviriga, Christopher W Cunningham and 2 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Evaluation of cannabimimetic effects of selected minor cannabinoids and Terpenoids in mice.Progress in neuro-psychopharmacology & biological psychiatry · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sara E KearneyDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Anghelo J GanganoDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0002-5577-5503
Daniel G BarrusAnalytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, North Carolina 27709, United States.
Kyle J RehrauerConcordia University Wisconsin School of Pharmacy, Mequon, Wisconsin 53097, United States.
Terry-Elinor R ReidConcordia University Wisconsin School of Pharmacy, Mequon, Wisconsin 53097, United States.
Primali V NavaratneDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.
Emily K TracyAnalytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, North Carolina 27709, United States.
Adrian RoitbergDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0003-3963-8784
Ion GhivirigaDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0001-5812-5170
Christopher W CunninghamConcordia University Wisconsin School of Pharmacy, Mequon, Wisconsin 53097, United States.ORCID 0000-0002-4468-2213
Thomas GamageAnalytical Chemistry and Pharmaceutics, RTI International, Research Triangle Park, North Carolina 27709, United States.ORCID 0000-0003-3528-9695
Alexander J GrenningDepartment of Chemistry, University of Florida, Gainesville, Florida 32611, United States.ORCID 0000-0002-8182-9464

Funding

Minor Cannabinoids and Terpenes: Preclinical Evaluation as AnalgesicsR01AT010773 · NCCIH · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2019 to 2024
$2.5M
New opportunities for the Cope rearrangement: methods, modular synthesis, and applications in drug discoveryR35GM137893 · NIGMS · UNIVERSITY OF MINNESOTA · PI GRENNING, ALEXANDER JAMES · 2020 to 2024
$1.8M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NCCIH NIH HHS R01 AT010773NIDA NIH HHS K01 DA045752NIGMS NIH HHS R35 GM137893NIH HHS S10 OD021758
6 · The paper itself

Abstract

The resorcinol-terpene phytocannabinoid template is a privileged scaffold for the development of diverse therapeutics targeting the endocannabinoid system. Axially chiral cannabinols (

Indexed as

CannabidiolCannabinoidsCannabinolEndocannabinoidsLigandsReceptors, CannabinoidCannabidiolCannabinoidsCannabinolEndocannabinoidsLigandsReceptors, Cannabinoid

Identifiers

PMID37314891
PMCPMC11392426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.