Evidence map›Paper›PMID 37314694›Full record

ArticleProbiotics and antimicrobial proteins2023

Lactobacillus reuteri CCFM1175 and Lactobacillus paracasei CCFM1176 Could Prevent Capsaicin-Induced Ileal and Colonic Injuries.

Bingyong Mao, Qunran Xiang, Xin Tang, Qiuxiang Zhang, Xiaoming Liu, Jianxin Zhao, Shumao Cui, Hao Zhang

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Article in Probiotics and antimicrobial proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The Role of ProbioticsInternational journal of molecular sciences · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Probiotics in Postoperative Pain Management.Journal of personalized medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bingyong MaoState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Qunran XiangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Xin TangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Qiuxiang ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Xiaoming LiuState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Jianxin ZhaoState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Shumao CuiState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China. cuishumao@jiangnan.edu.cn.
Hao ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Capsaicin (CAP) is usually reported to have many biological activities. However, a large intake of CAP may cause heartburn, gastrointestinal pain, and diarrhea. In this study, mice were gavaged with nine lactic acid bacteria (LAB) strains for two weeks, in which the mice were treated with CAP at the second week and lasted for one week. We tried to identify potential probiotics that could prevent CAP-induced intestinal injury and investigate the mechanisms. The modulation of transient receptor potential vanilloid 1 (TRPV1), levels of short-chain fatty acids (SCFAs), and the composition of gut microbiota were analyzed. The results showed that Lactobacillus reuteri CCFM1175 and Lactobacillus paracasei CCFM1176 effectively attenuated CAP-induced injuries to the ileum and colon, including relieving the damage to colonic crypt structures, increasing the number of goblet cells, decreasing levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), increasing levels of anti-inflammatory factors (IL-10), and reducing levels of substance P (SP) and calcitonin gene-related peptide (CGRP) in serum and colon tissue. Further analysis showed that L. reuteri CCFM1175 increased the relative abundance of Ruminococcaceae UCG_014 and Akkermansia. L. paracasei CCFM1176 downregulated the expression of TRPV1 in the ileal and colonic tissues and promoted the relative abundance of Ruminococcaceae UCG_014 and Lachnospiraceae UCG_006. These results indicate that L. reuteri CCFM1175 and L. paracasei CCFM1176 could prevent CAP-induced intestinal injury and be used as probiotics to improve the gastrointestinal health.

Indexed as

Lacticaseibacillus paracaseiLimosilactobacillus reuteriProbioticsAnimalsCapsaicinColonIleumMiceCapsaicinCapsaicinGut microbiotaIntestineProbiotics

Identifiers

PMID37314694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.