Evidence map›Paper›PMID 37314654›Full record

ArticleMolecular neurobiology2023

Reduced Cerebellar BDNF Availability Affects Postnatal Differentiation and Maturation of Granule Cells in a Mouse Model of Cholesterol Dyshomeostasis.

Micaela Lucarelli, Serena Camuso, Chiara Di Pietro, Francesco Bruno, Piergiorgio La Rosa, Daniela Marazziti, Maria Teresa Fiorenza, Sonia Canterini

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Micaela LucarelliDivision of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy.ORCID https://orcid.org/0000-0001-6181-4620
Serena CamusoDivision of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy.ORCID https://orcid.org/0000-0002-3116-6340
Chiara Di PietroInstitute of Biochemistry and Cell Biology, Italian National Research Council (CNR), I-00015, Monterotondo Scalo, Italy.ORCID https://orcid.org/0000-0002-2680-1821
Francesco BrunoRegional Neurogenetic Centre (CRN), Department of Primary Care, ASP, 88046, Lamezia Terme, Catanzaro, Italy.ORCID https://orcid.org/0000-0003-1377-4489
Piergiorgio La RosaDivision of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy.ORCID https://orcid.org/0000-0002-9723-2363
Daniela MarazzitiInstitute of Biochemistry and Cell Biology, Italian National Research Council (CNR), I-00015, Monterotondo Scalo, Italy.ORCID https://orcid.org/0000-0002-1582-9271
Maria Teresa FiorenzaDivision of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy.ORCID https://orcid.org/0000-0002-5079-4019
Sonia CanteriniDivision of Neuroscience, Dept. of Psychology, University La Sapienza, Rome, Italy. sonia.canterini@uniroma1.it.ORCID http://orcid.org/0000-0003-0911-7873
Fondazione Santa Lucia · ITNational Research Council · ITSapienza University of Rome · ITBioAge (Italy) · IT

Funding

Fondazione Telethon GSP20006_covid050
6 · The paper itself

Abstract

Niemann-Pick type C1 (NPC1) disease is a lysosomal lipid storage disorder due to mutations in the NPC1 gene resulting in the accumulation of cholesterol within the endosomal/lysosomal compartments. The prominent feature of the disorder is the progressive Purkinje cell degeneration leading to ataxia.In a mouse model of NPC1 disease, we have previously demonstrated that impaired Sonic hedgehog signaling causes defective proliferation of granule cells (GCs) and abnormal cerebellar morphogenesis. Studies conducted on cortical and hippocampal neurons indicate a functional interaction between Sonic hedgehog and brain-derived neurotrophic factor (BDNF) expression, leading us to hypothesize that BDNF signaling may be altered in Npc1 mutant mice, contributing to the onset of cerebellar alterations present in NPC1 disease before the appearance of signs of ataxia.We characterized the expression/localization patterns of the BDNF and its receptor, tropomyosin-related kinase B (TrkB), in the early postnatal and young adult cerebellum of the Npc1

Indexed as

Brain-Derived Neurotrophic FactorCerebellar AtaxiaAnimalsCell DifferentiationCerebellumCholesterolFemaleHedgehog ProteinsMiceNeuronsPurkinje CellsBrain-Derived Neurotrophic FactorCholesterolHedgehog ProteinsCerebellar glomerulusCerebellumNiemann-Pick type C1 diseaseNpc1TrkB receptor

Identifiers

PMID37314654
PMCPMC10415459
OpenAlexW4380576580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.