Evidence map›Paper›PMID 37313620›Full record

ArticleProtein science : a publication of the Protein Society2023

Protein salvage and repurposing in evolution: Phospholipase D toxins are stabilized by a remodeled scrap of a membrane association domain.

Matthew H J Cordes, Alexandra K Sundman, Holden C Fox, Greta J Binford

Open access · greenAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew H J CordesDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-5763-1669
Alexandra K SundmanDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Holden C FoxDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Greta J BinfordDepartment of Biology, Lewis & Clark College, Portland, Oregon, USA.
University of Arizona · USLewis & Clark College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The glycerophosphodiester phosphodiesterase (GDPD)-like SMaseD/PLD domain family, which includes phospholipase D (PLD) toxins in recluse spiders and actinobacteria, evolved anciently in bacteria from the GDPD. The PLD enzymes retained the core (β/α)

Indexed as

Phospholipase DAmino Acid SequenceBacteriaCatalytic DomainPhylogenySequence AlignmentPhospholipase Dchimeric domaindomain expansionphospholipase Dspider venomstructural evolution

Identifiers

PMID37313620
PMCPMC10303701
OpenAlexW4380576230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.