Trial reportDrug design, development and therapy2023
Perioperative Administration of Pregabalin and Esketamine to Prevent Chronic Pain After Breast Cancer Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study.BMC medicine · 2026Trial
- Efficacy and safety of esketamine hydrochloride injection at different dosages for patients undergoing radical thyroidectomy for thyroid cancer: a randomized trial.BMC anesthesiology · 2025Trial
- Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial.International journal of clinical pharmacy · 2025Trial
- Prevention of sufentanil-induced cough during induction of general anesthesia by low-dose esketamine.BMC anesthesiology · 2025Trial
- The Effect of Minimal-Dose S-Ketamine Administration Post-Surgery on Opioids Consumption and Functional Rehabilitation Exercises in Patients Undergoing Minimally Invasive Radical Resection of Esophageal Cancer.Therapeutics and clinical risk management · 2025Trial
- A Comparative Study of Esketamine-Propofol and Sufentanil-Propofol for Analgesia and Sedation During Breast Minimally Invasive Rotary Resection with Local Anesthesia: A Randomized Double-Blind Clinical Trial.Drug design, development and therapy · 2024Trial
- Effects of Esketamine Infusion by Patient-Controlled Intravenous Analgesia in Patients With Zoster-Associated Pain: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Esketamine/Ketamine: Dual-Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Interpreting the risk of postoperative post-neuraxial puncture-site pain after cesarean section: a machine learning approach evaluating nalbuphine infiltration along the epidural puncture tract in a prospective observational cohort.Frontiers in medicine · 2026Article
- Esketamine Enhances the Chemosensitivity of Colorectal Adenocarcinoma Cells to 5-Fluorouracil via AMPK/mTOR/HMMR Signaling Pathway.Oncology research · 2026Article
- Article
- Esketamine reduces postoperative depression in breast cancer through TREK-1 channel inhibition and neurotransmitter modulation.Cancer cell international · 2025Article
- The effect of an intravenous analgesic pump with esketamine on postoperative pain and postpartum depression in women with cesarean section.American journal of translational research · 2025Article
- Efficacy of esketamine for chronic post-thoracotomy pain: protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Prevention of Post-Mastectomy Pain Syndrome: A Review of Recent Literature on Perioperative Interventions.Current oncology reports · 2024Review
- Esketamine combined with sufentanilFrontiers in pharmacology · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Perioperative multimodal analgesia can prevent chronic pain after breast cancer surgery. This study aimed to investigate the efficacy of combined perioperative oral pregabalin and postoperative esketamine in preventing chronic pain after breast cancer surgery. Methods: Ninety patients undergoing elective breast cancer surgery were randomized into the combined pregabalin and esketamine group (EP group) and the general anesthesia alone group (Control group). The EP group received 150 mg of oral pregabalin 1 h before surgery and twice daily for seven days postoperatively, and a patient-controlled analgesia pump after surgery that delivered 100 μg sufentanil + 1.25 mg/kg esketamine + 4 mg tropisetron in 100 mL saline solution intravenously. The Control group received placebo capsules before and after the surgery and routine postoperative analgesia (100 μg sufentanil + 4 mg tropisetron in 100 mL saline solution). The primary outcome was the incidence of chronic pain three and six months after surgery. Secondary outcomes included acute postoperative pain, postoperative opioid consumption, and incidence of adverse events. Results: The incidence of chronic pain in the EP group was significantly lower than in the Control group three (14.3% vs 46.3%, Conclusion: Combined perioperative oral pregabalin and postoperative esketamine effectively prevented chronic pain after breast cancer surgery, improved acute postoperative pain, and reduced postoperative opioid consumption.
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