Evidence map›Paper›PMID 37313410›Full record

ArticleFrontiers in immunology2023

Differential recognition of influenza A virus H1N1 neuraminidase by DNA vaccine-induced antibodies in pigs and ferrets.

Jeanette Linnea Tingstedt, Christine Stephen, Christian Risinger, Ola Blixt, Vithiagaran Gunalan, Isik Somuncu Johansen, Anders Fomsgaard, Charlotta Polacek, Ria Lassaunière

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jeanette Linnea TingstedtVirus Research & Development Laboratory, Department of Virus & Microbiological Special Diagnostics Statens Serum Institut, Copenhagen, Denmark.
Christine StephenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, United States.
Christian RisingerDepartment of Chemistry, University of Copenhagen, Copenhagen, Denmark.
Ola BlixtDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark.
Vithiagaran GunalanVirus Research & Development Laboratory, Department of Virus & Microbiological Special Diagnostics Statens Serum Institut, Copenhagen, Denmark.
Isik Somuncu JohansenResearch Unit of Infectious Diseases, Clinical Institute, University of Southern Denmark, Odense, Denmark.
Anders FomsgaardVirus Research & Development Laboratory, Department of Virus & Microbiological Special Diagnostics Statens Serum Institut, Copenhagen, Denmark.
Charlotta PolacekVirus Research & Development Laboratory, Department of Virus & Microbiological Special Diagnostics Statens Serum Institut, Copenhagen, Denmark.
Ria LassaunièreVirus Research & Development Laboratory, Department of Virus & Microbiological Special Diagnostics Statens Serum Institut, Copenhagen, Denmark.
Statens Serum Institut · DKUniversity of Southern Denmark · DKTechnical University of Denmark · DKUniversity of California, San Diego · USUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuraminidase (NA) accounts for approximately 10-20% of the total glycoproteins on the surface of influenza viruses. It cleaves sialic acids on glycoproteins, which facilitates virus entry into the airways by cleaving heavily glycosylated mucins in mucus and the release of progeny virus from the surface of infected cells. These functions make NA an attractive vaccine target. To inform rational vaccine design, we define the functionality of influenza DNA vaccine-induced NA-specific antibodies relative to antigenic sites in pigs and ferrets challenged with a vaccine-homologous A/California/7/2009(H1N1)pdm09 strain. Sera collected pre-vaccination, post-vaccination and post-challenge were analyzed for antibody-mediated inhibition of NA activity using a recombinant H7N1

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H7N1 SubtypeInfluenza, HumanInfluenza VaccinesVaccines, DNAAnimalsAntibodies, ViralFerretsHumansNeuraminidaseSwineAntibodies, ViralInfluenza VaccinesNeuraminidaseVaccines, DNAantibodiesDNA vaccineELLAepitope mappinginfluenzaneuraminidaseneuraminidase inhibitionvaccines

Identifiers

PMID37313410
PMCPMC10258320
OpenAlexW4378716573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.