Evidence map›Paper›PMID 37313399›Full record

ArticleERJ open research2023

Lung microhaemorrhage drives oxidative/inflammatory damage in α

Cesare Saltini, Naweed Mohammad, Yan Xin, Rodolfo Alvarado, Andrew J Ghio, Craig G Moneypenny, Alberto Riva, Dongtao Fu, Tammy Flagg, Giovanni F A Saltini and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Heme-mediated selection of encapsulatedEmerging microbes & infections · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cesare SaltiniDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Naweed MohammadDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Yan XinNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA.
Rodolfo AlvaradoInterdisciplinary Center for Biotechnology Research, Electron Microscopy Core, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0003-4640-7757
Andrew J GhioUnited States Environmental Protection Agency, Chapel Hill, NC, USA.
Craig G MoneypennyDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Alberto RivaInterdisciplinary Center for Biotechnology Research, Bioinformatics Core, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0001-9150-8333
Dongtao FuDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Tammy FlaggDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Giovanni F A SaltiniDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Ivan ArisiBioinformatics Facility, European Brain Research Institute, Rome, Italy.
Kristianna M FredenburgDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Yang ZhangDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Jorge E LascanoDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
Mark BrantlyDivision of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID https://orcid.org/0000-0003-0189-1565

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Animal models using intratracheal instillation show that elastase, unopposed by α Methods: BAL samples (17 patients, 15 controls) were evaluated for free haem (iron protoporphyrin IX) and total iron concentrations. Alveolar macrophage activation patterns were assessed using RNA sequencing and validated Results: BAL collected from AATD patients showed significantly elevated free haem and total iron concentrations. Alveolar and interstitial macrophages in AATD explants showed elevated iron and ferritin accumulation in large lysosomes packed by iron oxide cores with degraded ferritin protein cages. BAL macrophage RNA sequencing showed innate pro-inflammatory activation, replicated Conclusions: BAL and tissue markers of alveolar haemorrhage, together with molecular and cellular evidence of macrophage innate pro-inflammatory activation and oxidative damage, are consistent with free haem stimulation. Overall, this initial study provides evidence for a pathogenetic role of elastase-induced alveolar haemorrhage in AATD emphysema.

Identifiers

PMID37313399
PMCPMC10258718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.