Evidence map›Paper›PMID 37313228›Full record

ArticleNeuropsychiatric disease and treatment2023

Aripiprazole Plasma Concentrations Delivered from Two 2-Month Long-Acting Injectable Formulations: An Indirect Comparison.

Matthew Harlin, Craig Chepke, Frank Larsen, Karimah S Bell Lynum, Sanjeda R Chumki, Heather Fitzgerald, Pedro Such, Jessica Madera-McDonough, Murat Yildirim, Moeen Panni and 1 more

Abstract read
In one paragraph

Article in Neuropsychiatric disease and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthew Harlin *Quantitative Pharmacology, Clinical Pharmacology, Early Phase & Translational Medicine, Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.ORCID 0000-0001-7087-2734
Craig Chepke *Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA.ORCID 0000-0002-4873-4770
Frank Larsen *Pharmacokinetic and Pharmacodynamic Modelling & Simulation, H. Lundbeck A/S, Valby, Denmark.ORCID 0000-0002-8318-1681
Karimah S Bell Lynum *US Medical Affairs, Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.ORCID 0000-0002-2045-9578
Sanjeda R Chumki *US Medical Affairs, Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.ORCID 0000-0002-5882-0920
Heather Fitzgerald *Medical Affairs, Lundbeck LLC, Deerfield, IL, USA.ORCID 0000-0001-7126-6701
Pedro Such *Medical Affairs, H. Lundbeck A/S, Valby, Denmark.ORCID 0000-0003-1905-1142
Jessica Madera-McDonough *Global Medical Affairs, Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.ORCID 0000-0003-2887-7480
Murat Yildirim *Medical Affairs, H. Lundbeck A/S, Valby, Denmark.ORCID 0000-0001-6192-1047
Moeen Panni *Global Medical Affairs, Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA.ORCID 0000-0001-8993-7702
Stephen R Saklad *Division of Pharmacotherapy, College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.ORCID 0000-0002-6181-138X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU 960) is a novel long-acting injectable (LAI) formulation of aripiprazole monohydrate for administration once every 2 months, developed for the treatment of schizophrenia or maintenance monotherapy treatment of bipolar I disorder in adults (indication will vary by country). Aripiprazole lauroxil 1064 mg (AL 1064) is an LAI formulation of aripiprazole lauroxil, an aripiprazole prodrug, for administration once every 2 months, indicated for the treatment of schizophrenia in adults. This analysis provides an indirect comparison of aripiprazole plasma concentrations following multiple doses of either formulation. Clinical trial data were used to determine average steady-state aripiprazole plasma concentration (C

Indexed as

antipsychoticbipolar I disorderlong-acting injectableschizophrenia

Identifiers

PMID37313228
PMCPMC10259522

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.