Evidence map›Paper›PMID 37313197›Full record

ArticleArchives of medical science : AMS2023

Mucin 1 expression correlation with lymph node metastasis and micrometastasis and poor prognosis in patients with esophageal squamous cell carcinomas.

Fei Yang, Zhe Li, Jing-Bo Shao, Wei Gao, Zhi-Gang Sun

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Article in Archives of medical science : AMS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Fei YangDepartment of Pathology, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Zhe LiDepartment of Medical Examination, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Jing-Bo ShaoWeifang Medical University, Weifang, Shandong Province, China.
Wei GaoDepartment of Pathology, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Zhi-Gang SunDepartment of Thoracic Surgery, Jinan Central Hospital Affiliated to Shandong University, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lymph node metastasis (LNM) and lymph node micrometastasis (LNMM) are prognostic factors in esophageal squamous cell carcinoma (ESCC) patients. The purpose of this research is to investigate whether mucin 1 expression detected by immunohistochemistry in lymph nodes correlates with LNM, LNMM and prognosis in ESCC patients. Material and methods: There were 92 ESCC patients enrolled in the research, and 1382 lymph nodes were obtained from these 92 patients. All lymph nodes were immunohistochemically analyzed using an anticytokeratin and mucin 1 antibody cocktail. Results: In the pN1-2 patients' group, 68 lymph nodes from 15 patients had tumor metastasis. All these 68 tumor metastatic lymph nodes were positive for mucin 1. Mucin 1 was detected in another 231 lymph nodes and among them, 3 (3/231 1.3%) lymph nodes from 2 (2/15 13.3%) patients were positive for mucin 1. In 77 pN0 patients, mucin 1 was detected in 1083 lymph nodes from the 77 patients; 17 (17/1083 1.6%) lymph nodes from 15 (15/77 19.5%) patients were positive for mucin 1. The 5-year survival rate was 39.1%, and it was significantly related to tumor invasion (pT, Conclusions: Mucin 1 expression was related to LNM and LNMM and poor prognosis in ESCC patients. Immunohistochemistry for mucin 1 can be applied for the detection of LNM and LNMM.

Indexed as

esophageal squamous cell carcinomalymph node metastasislymph node micrometastasismucin 1

Identifiers

PMID37313197
PMCPMC10259391

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