Evidence map›Paper›PMID 37312886›Full record

ArticleIEEE transactions on medical robotics and bionics2023

Motorized template for MRI-guided focal cryoablation of prostate cancer.

Pedro Moreira, John Grimble, Mariana C Bernardes, Nicusor Iftimia, Vincent M Levesque, Lori Foley, Kemal Tuncali, Junichi Tokuda, Jesung Park

Abstract read
In one paragraph

Article in IEEE transactions on medical robotics and bionics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Current Status of Cryoablation in Prostate Cancer Management.Clinical Medicine Insights. Oncology · 2025
    Review
  4. Review
  5. Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer.IEEE open journal of engineering in medicine and biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pedro MoreiraDepartment of Radiology at the Brigham and Women's Hospital and Harvard Medical School., Boston 02138 MA, USA.
John GrimblePhysical Science Inc., Andover 01810 MA, USA.
Mariana C BernardesDepartment of Radiology at the Brigham and Women's Hospital and Harvard Medical School., Boston 02138 MA, USA.
Nicusor IftimiaPhysical Science Inc., Andover 01810 MA, USA.
Vincent M LevesqueDepartment of Radiology at the Brigham and Women's Hospital and Harvard Medical School., Boston 02138 MA, USA.
Lori FoleyDepartment of Radiology at the Brigham and Women's Hospital and Harvard Medical School., Boston 02138 MA, USA.
Kemal TuncaliDepartment of Radiology at the Brigham and Women's Hospital and Harvard Medical School., Boston 02138 MA, USA.
Junichi TokudaDepartment of Radiology at the Brigham and Women's Hospital and Harvard Medical School., Boston 02138 MA, USA.
Jesung ParkPhysical Science Inc., Andover 01810 MA, USA.

Funding

TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Nobuhiko Hata, CLARE M TEMPANY · 2021 to 2026
$10.7M
Open Software Platform for Data-Driven Image-Guided Robotic InterventionsR01EB020667 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ-MERCADO, YANCY, KRIEGER, AXEL · 2015 to 2024
$4.1M
Adaptive Percutaneous Prostate Interventions using Sensorized NeedleR01CA235134 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Nobuhiko Hata, IULIAN IOAN IORDACHITA · 2019 to 2026
$3.6M
Smart Multi-grid Template for Focal Therapy of Prostate CancerR43EB032676 · NIBIB · PHYSICAL SCIENCES, INC · PI PARK, JESUNG · 2021 to 2021
$263k
NCI NIH HHS R01 CA235134NIBIB NIH HHS P41 EB028741NIBIB NIH HHS R01 EB020667NIBIB NIH HHS R43 EB032676
6 · The paper itself

Abstract

MR-guided focal cryoablation of prostate cancer has often been selected as a minimally-invasive treatment option. Placing multiple cryo-needles accurately to form an ablation volume that adequately covers the target volume is crucial for better oncological/functional outcomes. This paper presents an MRI-compatible system combining a motorized tilting grid template with insertion depth sensing capabilities, enabling the physician to precisely place the cryo-needles into the desired location. In vivo animal study in a swine model (3 animals) was performed to test the device performance including targeting accuracy and the procedure workflow. The study showed that the insertion depth feedback improved the 3D targeting accuracy when compared to the conventional insertion technique (7.4 mm vs. 11.2 mm, p=0.04). All three cases achieved full iceball coverage without repositioning the cryo-needles. The results demonstrate the advantages of the motorized tilting mechanism and real-time insertion depth feedback, as well as the feasibility of the proposed workflow for MRI-guided focal cryoablation of prostate cancer.

Indexed as

Focal therapyMR-conditional robotsMR-guided proceduresProstate cancer

Identifiers

PMID37312886
PMCPMC10259684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.