Evidence map›Paper›PMID 37312858›Full record

ArticleACS medicinal chemistry letters2023

Design, Synthesis, and Biological Activity of Thioguanine-Modified Pleuromutilin Derivatives.

Can Yong, Jianglin Yu, Chunxia Wu, Xiujuan Zhang, Yun Li, Chuan Xie, Xiaolong He, Dongfang Liu, Zhouyu Wang, Peng Lai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Can YongDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Jianglin YuDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Chunxia WuDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Xiujuan ZhangDepartment of Pharmaceutical Engineering, School of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Yun LiDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Chuan XieDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Xiaolong HeDepartment of Pharmaceutical Engineering, School of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Dongfang LiuDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Zhouyu WangDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.
Peng LaiDepartment of Pharmaceutical Engineering, School of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Yuanyuan ZhangDepartment of Chemistry, School of Science, Xihua University, Chengdu 610039, China.ORCID https://orcid.org/0000-0001-8722-1006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic overuse has caused the increasingly serious problem of bacterial drug resistance, with numerous marketed antibiotics exhibiting significantly reduced activity against drug-resistant bacteria. Therefore, there is urgent demand for the development of novel antibiotics. Pleuromutilin is a tricyclic diterpene exhibiting antibacterial activity against Gram-positive bacteria and is currently considered the most promising natural antibiotic. In this study, novel pleuromutilin derivatives were designed and synthesized by introducing thioguanine units, and their antibacterial activities against drug-resistant strains were evaluated

Identifiers

PMID37312858
PMCPMC10258896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.