Evidence map›Paper›PMID 37312853›Full record

ReviewACS medicinal chemistry letters2023

Recent Developments in Mass Spectrometry to Support Next-Generation Synthesis and Screening.

Nari N Talaty, Robert W Johnson, James Sawicki, Omprakash Nacham, Stevan W Djuric

Abstract readReview
In one paragraph

Review in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nari N TalatyDiscovery Platform Technologies, AbbVie Inc., North Chicago, Illinois 60064, United States.ORCID https://orcid.org/0000-0002-0701-4347
Robert W JohnsonDiscovery Platform Technologies, AbbVie Inc., North Chicago, Illinois 60064, United States.ORCID https://orcid.org/0000-0003-3404-5314
James SawickiDiscovery Platform Technologies, AbbVie Inc., North Chicago, Illinois 60064, United States.
Omprakash NachamDiscovery Platform Technologies, AbbVie Inc., North Chicago, Illinois 60064, United States.
Stevan W DjuricDiscovery Chemistry and Technology Consulting LLC, New Bern, North Carolina 28562, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complexity of new therapeutics continues to increase and the timeline for the discovery of these therapeutics continues to shrink. This creates demand for new analytical techniques to facilitate quicker discovery and development of novel drugs. Mass spectrometry is one of the most prolific analytical techniques that has been applied across the entire drug discovery pipeline. New mass spectrometers and the associated methods for sampling have been introduced at a rate that keeps pace with new chemistries, therapeutic types, and screening practices used by modern drug hunters. This microperspective covers application and implementation of new mass spectrometry workflows that enable current and future efforts in screening and synthesis for drug discovery.

Identifiers

PMID37312853
PMCPMC10258828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.