ArticleArchives of Razi Institute2023
The Relation between Increasing Anxiety and Prolactin-Releasing Peptide in Rats.
Article in Archives of Razi Institute, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Impact of high-fat diet and feeding time on daily anxious-like behaviors in aged male rats.Behavioral and brain functions : BBF · 2026Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PrRP, also known as prolactoliberin, is a bovine hypothalamic extract neurohormone that stimulates prolactin synthesis in a rat pituitary adenoma cell line and lactating rat pituitary cells. PrRP has been shown to control the intake of food and energy expenditure, but it may also have a role in stress sensitivity, reproduction, cardia productivity, secretion of endocrine components, and lately, neuroprotective characteristics, among others. The current study was performed to identify if prolactin-releasing peptide (PrRP) had any effect in increasing anxiety clinical features in rats as an animal model. The study included 114 Wistar handling-acclimated male rats (160 gm, 2 months old); divided randomly into three major groups. The rats were divided randomly into three major groups (38-control animals (38C), and 38-PrRP animals (38P), both were examined using the EPM test to test for stress-related signs, such as fear of height (5 mins duration for each rat). The maze was cleaned with water to eliminate the previous rat odor after the experiment for each rat was completed. The tests were performed between 13:00 to 17:00 of the day. Then, a week later, 38 (19-PrRP animals (19P) and 19-control animals (19C)) were examined using the SP test conducted between 13:00 to 16:00 of the day. Fifteen minutes before EPM, the 38C received intranasal 0.9%-10µl NaCl (per nostril), and 38P received intranasal 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.