Evidence map›Paper›PMID 37312619›Full record

ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2023

Guidelines for ex vivo mechanical testing of tendon.

Spencer P Lake, Jess G Snedeker, Vincent M Wang, Hani Awad, Hazel R C Screen, Stavros Thomopoulos

Abstract readReview
In one paragraph

Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx-Lineage Cells Accelerates Structural and Functional Recovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  15. Shear wave propagation as a noninvasive metric of loading and microdamage in tendon fascicles.Journal of the mechanical behavior of biomedical materials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Spencer P LakeDepartment of Mechanical Engineering & Materials Science, Washington University in St. Louis, St. Louis, Missouri, USA.
Jess G SnedekerUniversity Hospital Balgrist, ETH Zurich, Zurich, Switzerland.
Vincent M WangDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0001-5722-9146
Hani AwadDepartment of Orthopaedics, Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA.ORCID 0000-0003-2197-2610
Hazel R C ScreenSchool of Engineering & Materials Science, Queen Mary University of London, London, UK.
Stavros ThomopoulosDepartment of Orthopaedic Surgery, Department of Biomedical Engineering, Columbia University, New York, New York, USA.ORCID 0000-0003-1531-4849

Funding

Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Enhanced Tendon Healing Through Growth Factor and Cell TherapiesR01AR062947 · NIAMS · WASHINGTON UNIVERSITY · PI GELBERMAN, RICHARD H, THOMOPOULOS, STAVROS · 2012 to 2022
$5.5M
Strain Analysis Software for Open ScienceR01AR077793 · NIAMS · WASHINGTON UNIVERSITY · PI Guy M Genin, Stavros Thomopoulos · 2020 to 2026
$5.2M
Engineering scarless repair of flexor tendon injuriesR01AR056696 · NIAMS · UNIVERSITY OF ROCHESTER · PI AWAD, HANI A, BENOIT, DANIELLE S. · 2009 to 2019
$3.6M
Formation of a functional tendon enthesis during development and healingR01AR080717 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Thomopoulos · 2023 to 2026
$1.9M
NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR056696NIAMS NIH HHS R01 AR062947NIAMS NIH HHS R01 AR077793NIAMS NIH HHS R01 AR080717
6 · The paper itself

Abstract

Tendons are critical for the biomechanical function of joints. Tendons connect muscles to bones and allow for the transmission of muscle forces to facilitate joint motion. Therefore, characterizing the tensile mechanical properties of tendons is important for the assessment of functional tendon health and efficacy of treatments for acute and chronic injuries. In this guidelines paper, we review methodological considerations, testing protocols, and key outcome measures for mechanical testing of tendons. The goal of the paper is to present a simple set of guidelines to the nonexpert seeking to perform tendon mechanical tests. The suggested approaches provide rigorous and consistent methodologies for standardized biomechanical characterization of tendon and reporting requirements across laboratories.

Indexed as

MusclesTendonsBiomechanical PhenomenaMechanical TestsTensile Strengthbiomechanicstendon

Identifiers

PMID37312619
PMCPMC10528429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.