Evidence map›Paper›PMID 37312537›Full record

ArticleCartilage2024

Associations of Changes in Knee Hyaline Cartilage Composition Measured With Dual-Energy Computed Tomography in Gout, Aging and Osteoarthritis.

Julie Legrand, Claire Marzin, Tuhina Neogi, Laurène Norberciak, Jean-François Budzik, Tristan Pascart

Open access · hybridAbstract read
In one paragraph

Article in Cartilage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Computed tomography-current status and future directions for arthritis imaging.Therapeutic advances in musculoskeletal disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Julie LegrandDepartment of Diagnostic and Interventional Imaging, Lille Catholic Hospitals, University of Lille, Lomme, France.ORCID 0000-0002-4937-6602
Claire MarzinDepartment of Diagnostic and Interventional Imaging, Lille Catholic Hospitals, University of Lille, Lomme, France.
Tuhina NeogiSection of Rheumatology, Boston University School of Medicine, Boston, MA, USA.
Laurène NorberciakDepartment of Medical Research, Biostatistics, Lille Catholic Hospitals, University of Lille, Lomme, France.
Jean-François BudzikDepartment of Diagnostic and Interventional Imaging, Lille Catholic Hospitals, University of Lille, Lomme, France.
Tristan PascartMabLab UR4490/Lille and Boulogne-sur-Mer Universities/University of Lille Nord de France, Lomme, France.
Université Catholique de Lille · FRBoston University · US

Funding

Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2019 to 2026
$6.9M
The Role of Urate in Knee Osteoarthritis-Related Inflammation, Pathology and PainK24AR070892 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TUHINA NEOGI · 2017 to 2026
$1.1M
NIAMS NIH HHS K24 AR070892NIAMS NIH HHS P30 AR072571
6 · The paper itself

Abstract

objectiveTo characterize dual-energy computed tomography (DECT) changes depicting hyaline cartilage changes in gout patients with and without osteoarthritis (OA) and in comparators without gout.

designPatients with suspected crystal-associated arthropathy were enrolled and underwent bilateral DECT scans of the knees. Standardized regions of interest were defined in the femorotibial hyaline cartilage. Five DECT parameters were obtained: CT numbers in Hounsfield units (HU) at 80 and 140 kV, the electron density (Rho), the effective atomic number (Z

resultsA total of 113 patients with gout (mean age 63.5 ± 14.3 years) and 15 comparators without gout (mean age 75.8 ± 11.5 years) were included,

conclusionGout was associated with DECT-detected changes in cartilage composition, similar to those observed in older patients, with some similarities and some differences to those seen in OA. These results suggest the possibility of potential DECT biomarkers of OA.

Indexed as

GoutHyaline CartilageKnee JointOsteoarthritis, KneeTomography, X-Ray ComputedAgedAged, 80 and overAgingFemaleHumansMaleMiddle Agedagingcartilagedual-energy computed tomographygoutkneemonosodium urateosteoarthritisultrasonography

Identifiers

PMID37312537
PMCPMC11418446
OpenAlexW4380479713

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.