Evidence map›Paper›PMID 37312437›Full record

ArticleACR open rheumatology2023

Biologics Initiation in Rheumatoid Arthritis by Race and Ethnicity: Results From a Randomized Survey Study.

Julia F Simard, Rong Lu, Titilola O Falasinnu, Matthew C Baker, Saadiya Hawa, Mariani D Deluna, Audra Horomanski, Robert M Fairchild

Open access · goldAbstract read
In one paragraph

Article in ACR open rheumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Julia F SimardStanford Medicine, Stanford, California.ORCID https://orcid.org/0000-0001-5735-9856
Rong LuStanford Medicine, Stanford, California.
Titilola O FalasinnuStanford Medicine, Stanford, California.
Matthew C BakerStanford Medicine, Stanford, California.ORCID https://orcid.org/0000-0002-0002-1907
Saadiya HawaStanford Medicine, Stanford, California.ORCID https://orcid.org/0000-0001-6763-2035
Mariani D DelunaStanford Medicine, Stanford, California.
Audra HoromanskiStanford Medicine, Stanford, California.ORCID https://orcid.org/0000-0002-5084-4389
Robert M FairchildStanford Medicine, Stanford, California.
Stanford Medicine · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Implicit Bias in the Evidence: An Evaluation of Female-Predominant DiseaseR01AI154533 · NIAID · STANFORD UNIVERSITY · PI SIMARD, JULIA F · 2020 to 2023
$2.1M
NCATS NIH HHS UL1 TR003142
6 · The paper itself

Abstract

objectiveTo investigate whether the race and ethnicity of a patient with rheumatoid arthritis (RA) influences rheumatologists' likelihood of choosing to initiate biologic disease-modifying antirheumatic drug (bDMARD) treatment.

methodsWe conducted a randomized survey experiment in which identical brief case vignettes of hypothetical patients with RA were sent to US rheumatologists (respondents). Three of the four cases included some level of treatment decision ambiguity whereas the fourth case strongly favored bDMARD initiation. Each respondent was shown the four case vignettes, with the race and ethnicity (Black, Hispanic, White) randomly assigned for each case. Each vignette offered multiple choices for next therapeutic step, which we summarized using frequencies and proportions by race and ethnicity version.

resultsAmong 159 US rheumatologists, we found that for the three cases with some level of treatment decision ambiguity, there was little to no variability in the proportions of respondents who chose to start a biologic for the Black and Hispanic variants (cases 1, 2, and 3). For case 4, respondents generally agreed to start a biologic with some minimal variability across the variants (92.6% for the Black version, 98.1% for the Hispanic version, and 96.2% for the White version).

conclusionThere are conflicting data regarding bDMARD use and initiation in patients with RA based on the sex and race of the patient. This work adds to this conversation by examining how the next therapeutic step chosen by rheumatologists varied by the race and ethnicity of the hypothetical patient.

Identifiers

PMID37312437
PMCPMC10349254
OpenAlexW4380576523

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.