Evidence map›Paper›PMID 37312283›Full record

ArticleJournal of diabetes investigation2023

A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes.

Leonard C Harrison, Esther Bandala-Sanchez, Helena Oakey, Peter G Colman, Kelly Watson, Ki Wook Kim, Roy Wu, Emma E Hamilton-Williams, Natalie L Stone, Aveni Haynes and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 2 countries.

Leonard C HarrisonWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-2500-8944
Esther Bandala-SanchezWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Helena OakeyRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-1057-7615
Peter G ColmanDepartment of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Kelly WatsonDepartment of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Ki Wook KimVirology Research Laboratory, Serology and Virology Division, NSW Health, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Roy WuVirology Research Laboratory, Serology and Virology Division, NSW Health, Prince of Wales Hospital, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-0910-2399
Emma E Hamilton-WilliamsFrazer Institute, The University of Queensland, Brisbane, Queensland, Australia.
Natalie L StoneWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Aveni HaynesTelethon Kids Institute for Child Health Research, Centre for Child Health Research, the University of Western Australia, Perth, Western Australia, Australia.
Rebecca L ThomsonRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Peter J VuillerminFaculty of School of Medicine, Deakin University, Geelong, Victoria, Australia.
Georgia SoldatosMonash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
William D RawlinsonVirology Research Laboratory, Serology and Virology Division, NSW Health, Prince of Wales Hospital, Sydney, New South Wales, Australia.
Kelly J McGormRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Grant MorahanCentre for Diabetes Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
Simon C BarryRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Richard O SinnottMelbourne eResearch Group, School of Computing and Information Services, University of Melbourne, Melbourne, Victoria, Australia.
John M WentworthWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Jennifer J CouperRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Megan As PennoRobinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
ENDIA Study Group
The University of Adelaide · AUThe University of Melbourne · AUNew South Wales Department of Health · AUThe Royal Melbourne Hospital · AUAssociated Press · USBarwon Health · AUMonash Health · AUThe Kids Research Institute Australia · AUThe University of Queensland · AUThe University of Western Australia · AUWomen's and Children's Hospital · AU

Funding

Diabetes South AustraliaJuvenile Diabetes Research Foundation Australia and The Leona M. and Harry B. Helmsley Charitable Trust 3-SRA-2019-899-M-NJuvenile Diabetes Research Foundation Australia and The Leona M. and Harry B. Helmsley Charitable Trust 3-SRA-2020-966-M-NJuvenile Diabetes Research Foundation Australia International Strategic Research Award scheme 3-SRA-2017-417-A-NNHMRC Investigator Fellowship APP1173945NHMRC Practitioner Fellowship APP1136735NHMRC Research Institute Infrastructure Support SchemeThe National Health and Medical Research Council of Australia APP1078106Victorian State Government Operational Infrastructure Support Scheme
6 · The paper itself

Abstract

AIMS/

introductionAutoantibodies to pancreatic islet antigens identify young children at high risk of type 1 diabetes. On a background of genetic susceptibility, islet autoimmunity is thought to be driven by environmental factors, of which enteric viruses are prime candidates. We sought evidence for enteric pathology in children genetically at-risk for type 1 diabetes followed from birth who had developed islet autoantibodies ("seroconverted"), by measuring mucosa-associated cytokines in their sera. MATERIALS AND

methodsSera were collected 3 monthly from birth from children with a first-degree type 1 diabetes relative, in the Environmental Determinants of Islet Autoimmunity (ENDIA) study. Children who seroconverted were matched for sex, age, and sample availability with seronegative children. Luminex xMap technology was used to measure serum cytokines.

resultsOf eight children who seroconverted, for whom serum samples were available at least 6 months before and after seroconversion, the serum concentrations of mucosa-associated cytokines IL-21, IL-22, IL-25, and IL-10, the Th17-related cytokines IL-17F and IL-23, as well as IL-33, IFN-γ, and IL-4, peaked from a low baseline in seven around the time of seroconversion and in one preceding seroconversion. These changes were not detected in eight sex- and age-matched seronegative controls, or in a separate cohort of 11 unmatched seronegative children.

conclusionsIn a cohort of children at risk for type 1 diabetes followed from birth, a transient, systemic increase in mucosa-associated cytokines around the time of seroconversion lends support to the view that mucosal infection, e.g., by an enteric virus, may drive the development of islet autoimmunity.

Indexed as

Diabetes Mellitus, Type 1Islets of LangerhansAutoantibodiesAutoimmunityChildChild, PreschoolCytokinesHumansInfantSeroconversionAutoantibodiesCytokinesIslet autoantibodySeroconversionSerum cytokine

Identifiers

PMID37312283
PMCPMC10445231
OpenAlexW4380442252

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.