ArticleMolecular plant pathology2023
The PcMYB44-mediated miR397-PcLACs module regulates defence-induced lignification in pear resistance to fungal disease.
Article in Molecular plant pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 25 citations in OpenAlex.
- PbSnRK1-Mediated Phosphorylation of PbTCP13 Regulates Glucose-Responsive Lignin Biosynthesis via PbMYB11 During Pear Stone Cell Formation.Plant biotechnology journal · 2026Article
- Transcriptome-wide identification of R2R3-MYB protein family and functional analysis of CpMYB44 in Cyclocarya paliurus during Colletotrichum fructicola infection.Pest management science · 2026Article
- The MdERF1B-miR482c-Horticulture research · 2026Article
- A Csi-miR3954b-CsCE70/CsPLA1 Regulatory Module Enhances Citrus Fruit Resistance to Penicillium digitatum by Promoting Phenolic Acid and Flavonoid Biosynthesis.Molecular plant pathology · 2026Article
- A MaERF110-MaMYB308 Transcriptional Module Negatively Regulates Lignin-Mediated Defence Against Fusarium Wilt in Banana.Plant biotechnology journal · 2026Article
- Article
- Transcriptomic and metabolomic analysis between Rose varieties which are resistant or susceptible to Alternaria alternata.Functional & integrative genomics · 2026Article
- MicroRNA-mediated regulation of cell wall dynamics and intercellular communication under stress.Frontiers in plant science · 2026Review
- Factors underlying a latitudinal gradient in the S/G lignin monomer ratio in natural poplar variants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Cotton Laccase Confers Disease Resistance Against Verticillium dahliae by Promoting Cell Wall Lignification.Molecular plant pathology · 2025Article
- The long non-coding RNA MSTRG.32189-PcmiR399b-Horticulture research · 2025Article
- Balancing growth and defense: miRNA-mediated regulation of phosphorus allocation and antiviral immunity in soybean under normal light and shade.Frontiers in plant science · 2025Article
- The MdERF61-mdm-miR397b-MdLAC7b module regulates apple resistance to Fusarium solani via lignin biosynthesis.Plant physiology · 2024Article
- CsLAC4, regulated by CsmiR397a, confers drought tolerance to the tea plant by enhancing lignin biosynthesis.Stress biology · 2024Article
- TheHorticulture research · 2024Article
- Transcriptome analysis under pecan scab infection reveals the molecular mechanisms of the defense response in pecans.PloS one · 2024Article
- Genome-wide identification and expression patterns of the laccase gene family in response to kiwifruit bacterial canker infection.BMC plant biology · 2023Article
- Contribution of theInternational journal of molecular sciences · 2023Review
- The PcMYB44-mediated miR397-PcLACs module regulates defence-induced lignification in pear resistance to fungal disease.Molecular plant pathology · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
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Abstract
Diseases caused by Alternaria alternata and Botryosphaeria dothidea diminish pear yield and quality, and restrict the pear agricultural industry. Lignification is a conserved mechanism for plant resistance against pathogen invasion. The regulatory mechanisms underlying defence-induced lignification in pear in response to fungal pathogen infection remain unknown. In this study, analysis of lignification level and lignin content in pear revealed that A. alternata and B. dothidea induced lignification, and transcriptomics showed that lignin biosynthesis was affected. To explore whether laccases (LACs) mediated by miR397 regulate lignification in pear, we investigated the role of PcmiR397 in repressing the expression of PcLACs using 5'-RNA ligase-mediated-RACE and co-transformation in tobacco. Opposite expression patterns for PcmiR397 and PcLAC target genes were observed in pear in response to pathogens. Transient transformation in pear demonstrated that silencing PcmiR397 and overexpressing a single PcLAC enhanced resistance to pathogens via lignin synthesis. To further reveal the mechanism underpinning the PcMIR397 response of pear to pathogens, the PcMIR397 promoter was analysed, and pMIR397-1039 was found to be inhibited by pathogen infection. The transcription factor PcMYB44 was up-regulated, and it bound to the PcMIR397 promoter and inhibited transcription following pathogen infection. The results demonstrate the role of PcmiR397-PcLACs in broad-spectrum resistance to fungal disease, and the potential role of PcMYB44 involved in the miR397-PcLAC module in regulating defence-induced lignification. The findings provide valuable candidate gene resources and guidance for molecular breeding to improve resistance to fungal disease in pear.
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