ArticleCardiovascular diabetology2023
Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 2 of them syntheses that pooled it.
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Who cites it
159 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between triglyceride glucose index and risk of acute kidney injury in critically ill patients: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Triglyceride-glucose index and the risk of in-hospital and ICU all-cause mortality: a systematic review and meta-analysis of observational studies.Nutrition & diabetes · 2025Pooled it
- Association of Estimated Glucose Disposal Rate With Prevalent Kidney Stones: A Large-Scale Cross-Sectional Study in China.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Article
- TyG index and TyG-WHtR as predictors of all-cause mortality in patients with prior hepatitis A or B virus infections.BMC infectious diseases · 2026Article
- Diabetes-TyG interaction and mortality in critical cerebrovascular disease: a retrospective cohort study.Scientific reports · 2026Article
- Association between lactate-to-albumin ratio and the short-time mortality of patients with ischemic stroke in intensive care unit.BMC neurology · 2026Article
- Association of the triglyceride-glucose index with one-year all-cause mortality in patients with spontaneous basal ganglia hemorrhage: a retrospective study.BMC neurology · 2026Article
- Combined assessment of triglyceride-glucose index and stress hyperglycemia ratio to predict all-cause mortality in critically ill patients with intracerebral hemorrhage.BMC neurology · 2026Article
- An Inverted U-shaped Relationship between Glycemic Variability and Mortality in Patients with Severe Pulmonary Embolism: A Retrospective Study.Journal of atherosclerosis and thrombosis · 2026Article
- Article
- Research Topics and Trends in MIMIC-IV: A Large ICU Database Relevant for Critical Care Nursing.Nursing in critical care · 2026Review
- Article
- Development and external validation of a predictive model for in-hospital mortality in patients with liver cirrhosis and sepsis.Scientific reports · 2026Article
- Effect of Small Dense Low-Density Lipoprotein Cholesterol Combined With High-Sensitivity C-Reactive Protein on Cardiometabolic Multimorbidity: A National Cohort Study.Clinical cardiology · 2026Observational
- Triglyceride-glucose-based predictive model for in-hospital mortality in older acute myocardial infarction patients with multimorbidity.Internal and emergency medicine · 2026Article
- Retrospective Cohort Analysis of TyG, TyG-SI, and TyG-Lac Indices as Predictors of 360-Day Mortality in Critically Ill Ischemic Stroke Patients.Journal of clinical medicine · 2026Article
- The joint association of the combined triglyceride-glucose index and atherogenic index of plasma with hypertension on stroke risk across different glycemic status: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Association of triglyceride-glucose index fluctuation with in-hospital all-cause mortality in critically ill patients: a multidatabase retrospective study.Scientific reports · 2026Observational
- Triglyceride-glucose index as a potential evaluation tool for all-cause mortality in ischemic stroke patients undergoing endovascular therapy: a multicenter cohort study.BMC endocrine disorders · 2026Observational
99 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
backgroundThe triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG index in patients with severe stroke requiring ICU admission remains unclear. The aim of this study was to investigate the association between the TyG index and clinical prognosis of critically ill patients with ischemic stroke (IS).
methodsThis study identified patients with severe IS requiring ICU admission from the Medical Information Mart for Intensive Care (MIMIC-IV) database, and divided them into quartiles based on TyG index level. The outcomes included in-hospital mortality and ICU mortality. The association between the TyG index and clinical outcomes in critically ill patients with IS was elucidated using Cox proportional hazards regression analysis and restricted cubic splines.
resultsA total of 733 patients (55.8% male) were enrolled. The hospital mortality and intensive care unit (ICU) mortality reached 19.0% and 14.9%, respectively. Multivariate Cox proportional hazards analysis showed that the elevated TyG index was significantly related to all-cause death. After confounders adjusting, patients with an elevated TyG index had a significant association with hospital mortality (adjusted hazard ratio, 1.371; 95% confidence interval, 1.053-1.784; P = 0.013) and ICU mortality (adjusted hazard ratio, 1.653; 95% confidence interval, 1.244-2.197; P = 0.001). Restricted cubic splines revealed that a progressively increasing risk of all-cause mortality was related to an elevated TyG index.
conclusionThe TyG index has a significant association with hospital and ICU all-cause death in critically ill patients with IS. This finding demonstrates that the TyG index might be useful in identifying patients with IS at high risk of all-cause death.
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