Experimental carotid baroreceptor stimulation reduces blood flow velocities in the anterior and middle cerebral arteries of healthy individuals.

Gustavo A Reyes Del Paso, Casandra I Montoro, J Richard Jennings, Stefan Duschek

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Article in The journal of physiological sciences : JPS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Gustavo A Reyes Del PasoDepartment of Psychology, University of Jaén, 23071, Jaén, Spain.

Casandra I MontoroDepartment of Psychology, University of Jaén, 23071, Jaén, Spain. imontoro@ujaen.es.ORCID 0000-0003-4145-8600

J Richard JenningsDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, USA.

Stefan DuschekUMIT TIROL - University for Health Sciences and Technology, Hall in Tirol, Austria.

Funding

Spanish Ministry of Science and Innovation RTI2018-095830-B-I00/AEI/ 10.13039/501100011033

6 · The paper itself

Abstract

This study investigated effects of experimental baroreceptor stimulation on bilateral blood flow velocities in the anterior and middle cerebral arteries (ACA and MCA) using functional transcranial Doppler sonography. Carotid baroreceptors were stimulated by neck suction in 33 healthy participants. Therefore, negative pressure (- 50 mmHg) was applied; neck pressure (+ 10 mmHg) was used as a control condition. Heart rate (HR) and blood pressure (BP) were also continuously recorded. Neck suction led to reductions in bilateral ACA and MCA blood flow velocities, which accompanied the expected HR and BP decreases; HR and BP decreases correlated positively with the ACA flow velocity decline. The observations suggest reduction of blood flow in the perfusion territories of the ACA and MCA during baroreceptor stimulation. Baroreceptor-related HR and BP decreases may contribute to the cerebral blood flow decline. The findings underline the interaction between peripheral and cerebral hemodynamic regulation in autoregulatory control of cerebral perfusion.

Indexed as

Middle Cerebral ArteryPressoreceptorsBlood Flow VelocityBlood PressureHeart RateHumansBaroreceptorBlood pressureCerebral blood flowHeart rateTranscranial Doppler sonography

Identifiers

PMID37312034

DOI10.1186/s12576-023-00871-7

PMCPMC10717056

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