Evidence map›Paper›PMID 37311816›Full record

ArticleScientific reports2023

Mechanism of remodeling and local effects in vivo of a new injectable cosmetic filler.

Likui Sun, Xiaoxia Sun, Wenting Ruan, Guoxi Che, Fuyu Zhu, Chenghu Liu, Min Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Likui SunShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China. sunlikui2002@126.com.
Xiaoxia SunShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China.
Wenting RuanShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China.
Guoxi CheShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China.
Fuyu ZhuShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China.
Chenghu LiuShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China.
Min WanShandong Institute of Medical Device and Pharmaceutical Packaging Inspection (National Medical Products Administration Jinan Quality Supervision and Inspection Center for Medical Devices), which is NMPA Key laboratory for Safety Evaluation of Biomaterials and Medical Devices, Key lab of biological evaluation of medical devices of Shandong province, Jinan, 250101, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By studying the local effects of a new type of injectable cosmetic filler implanted into the animal to explore the mechanism of remodeling and cosmetic effect of this kind of product. Take 12 rabbits and select 4 implantation points on both sides of the spine, respectively, and implant the test sample (PLLA) and negative control sample (HDPE) into the subcutaneous tissues on both sides. In the same way, take another 12 rabbits and implant the marketing control sample (cross-linked sodium hyaluronate) and negative control sample (HDPE) into the subcutaneous tissues on both sides. The animals were executed at 1 week, 4 weeks, 13 weeks and 52 weeks respectively, and Hematoxylin-Eosin staining, Masson trichrome staining and immunofluorescence staining were performed to characterize the local effects in vivo and the expression of type I collagen (Col. I), type III collagen (Col.III) and matrix metalloproteinase 9 (MMP-9). Good histocompatibility of the test sample and the marketing control sample were found. The foreign body reaction of marketing control sample was more intense than that of the test sample after 13 weeks. The foreign body reaction of testing sample was more intense after 52 weeks, while that of the marketing control sample was more stable. With the process of tissue repair, the collagen fibers of test samples and marketing control samples gradually increased after implantation. Type I collagen was mainly found inside the fiber capsule, while type III collagen was mainly found outside. The positive expression of matrix metalloproteinase 9 gradually increased, the positive expression of test samples increased significantly after 52 weeks, while that of marketing control samples did not change significantly. Good histocompatibility of PLLA filler is found. Matrix metalloproteinase 9 participates in foreign body reaction and collagen formation, which can reflect the process of tissue remodeling.

Indexed as

CosmeticsLagomorphaAnimalsCollagen Type ICollagen Type IIIExcipientsForeign-Body ReactionMatrix Metalloproteinase 9PolyethyleneRabbitsCollagen Type ICollagen Type IIICosmeticsExcipientsMatrix Metalloproteinase 9Polyethylene

Identifiers

PMID37311816
PMCPMC10264432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.