ArticleCommunications biology2023
BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Proteomics of multimorbidity progression across cardiometabolic diseases and cancer in a multinational cohort.Cardiovascular diabetology · 2026Article
- scParadise: tunable, highly accurate multi-level cell type annotation, unknown cell type identification, and modality imputation.Nucleic acids research · 2026Article
- BMPER induces the adipogenic differentiation of fibro/adipogenic progenitors and promotes intramuscular fat deposition in chickens.Journal of animal science and biotechnology · 2026Article
- Heterogeneity and Clinical Relevance of Human Adipose Stromal and Progenitor Cells.Diabetes & metabolism journal · 2026Review
- Adipocyte NADH dehydrogenase reverses circadian and diet-induced metabolic syndrome.Nature metabolism · 2026Article
- Population structure, regions of homozygosity (ROH) and selection signal of two domesitic goat breeds revealed by whole-genome resequencing.BMC genomics · 2026Article
- Peptide codes for organ-selective mRNA delivery.Nature materials · 2026Article
- NADH dehydrogenase reverses dietary and clock metabolic syndrome.bioRxiv : the preprint server for biology · 2025Article
- Intramuscular adipose tissue restricts functional muscle recovery.Cell reports · 2025Article
- A multi-tissue and -breed catalogue of chromatin conformations and their implications in gene regulation in pigs.BMC genomics · 2025Article
- Article
- Single-Nucleus RNA Sequencing Reveals Muscle-Region-Specific Differences in Fibro-Adipogenic Progenitors Driving Intramuscular Fat Accumulation.Metabolites · 2025Article
- Single-cell transcriptomics of clinical grade adipose-derived regenerative cells reveals consistency between donors independent of gender and BMI.Stem cell research & therapy · 2025Article
- Transcriptome analysis of adipose tissue and muscle of Laiwu and Duroc pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Anatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues.Frontiers in physiology · 2024Article
- White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle.Biology · 2023Review
- Mesenchymal stromal cells as conductors of adipose tissue remodeling.Genes & development · 2023Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Autocrine and paracrine signaling regulating adipogenesis in white adipose tissue remains largely unclear. Here we used single-cell RNA-sequencing (RNA-seq) and single nuclei RNA-sequencing (snRNA-seq) to identify markers of adipose progenitor cells (APCs) and adipogenic modulators in visceral adipose tissue (VAT) of humans and mice. Our study confirmed the presence of major cellular clusters in humans and mice and established important sex and diet-specific dissimilarities in cell proportions. Here we show that bone morphogenetic protein (BMP)-binding endothelial regulator (BMPER) is a conserved marker for APCs and adipocytes in VAT in humans and mice. Further, BMPER is highly enriched in lineage negative stromal vascular cells and its expression is significantly higher in visceral compared to subcutaneous APCs in mice. BMPER expression and release peaked by day four post-differentiation in 3T3-L1 preadipocytes. We reveal that BMPER is required for adipogenesis both in 3T3-L1 preadipocytes and in mouse APCs. Together, this study identified BMPER as a positive modulator of adipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.