Evidence map›Paper›PMID 37311798›Full record

ArticleScientific reports2023

D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation.

Oluwarotimi O Folorunso, Stephanie E Brown, Jugajyoti Baruah, Theresa L Harvey, Shekib A Jami, Inna Radzishevsky, Herman Wolosker, James M McNally, John A Gray, Anju Vasudevan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Oluwarotimi O FolorunsoDivision of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA. ofolorunso@mclean.harvard.edu.
Stephanie E BrownDivision of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
Jugajyoti BaruahDivision of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
Theresa L HarveyDivision of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
Shekib A JamiCenter for Neuroscience, University of California Davis, Davis, CA, 95616, USA.
Inna RadzishevskyDepartment of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Herman WoloskerDepartment of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
James M McNallyDepartment of Psychiatry, Harvard Medical School, Boston, MA, 02215, USA.
John A GrayCenter for Neuroscience, University of California Davis, Davis, CA, 95616, USA.
Anju VasudevanAngiogenesis and Brain Development Laboratory, Department of Neurosciences, Huntington Medical Research Institutes (HMRI), Pasadena, CA, 91105, USA.
Darrick T BaluDivision of Basic Neuroscience, McLean Hospital, Belmont, MA, 02478, USA.
McLean Hospital · USHarvard University · USTechnion – Israel Institute of Technology · ILUniversity of California, Davis · USHuntington Medical Research Institutes · US

Funding

Novel Developmental Pathways Underlying Psychiatric DisordersR01MH110438 · NIMH · MCLEAN HOSPITAL · PI Anju Vasudevan · 2016 to 2026
$4.7M
Stabilizing the Tripartite Synaptic Complex Following TBIR01NS098740 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Joacir Graciolli Graciolli Cordeiro, Daniel Jon Liebl · 2017 to 2026
$4.7M
Function and Regulation of Postsynaptic Serine RacemaseR01MH117130 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GRAY, JOHN ALAN · 2019 to 2023
$2.4M
Training to Enhance Alignment of Psychiatry and NeuroscienceT32MH125786 · NIMH · MCLEAN HOSPITAL · PI William A. Carlezon, KERRY J. RESSLER · 2021 to 2026
$2.0M
Novel Autonomous Roles of CNS AngiogenesisR01NS100808 · NINDS · MCLEAN HOSPITAL · PI VASUDEVAN, ANJU · 2017 to 2021
$1.7M
Subcortical influence on the respiratory coordination of cortical neurodynamicsrelated to cognitionR21MH125242 · NIMH · HARVARD MEDICAL SCHOOL · PI MCKENNA, JAMES TIMOTHY, MCNALLY, JAMES M · 2021 to 2022
$363k
Defining the Role of Glial D-serine in Alzheimer's DiseaseR03AG063201 · NIA · MCLEAN HOSPITAL · PI BALU, DARRICK T · 2019 to 2020
$328k
BLRD VA I01 BX004500NIA NIH HHS 1R03AG063201-01NIA NIH HHS R03 AG063201NIMH NIH HHS R01 MH110438NIMH NIH HHS R01MH110438NIMH NIH HHS R01 MH117130NIMH NIH HHS R01MH117130NIMH NIH HHS R21 MH125242NIMH NIH HHS R21MH125242NIMH NIH HHS T32 MH125786NINDS NIH HHS R01 NS098740NINDS NIH HHS R01 NS100808NINDS NIH HHS R01NS100808
6 · The paper itself

Abstract

The proper development and function of telencephalic GABAergic interneurons is critical for maintaining the excitation and inhibition (E/I) balance in cortical circuits. Glutamate contributes to cortical interneuron (CIN) development via N-methyl-D-aspartate receptors (NMDARs). NMDAR activation requires the binding of a co-agonist, either glycine or D-serine. D-serine (co-agonist at many mature forebrain synapses) is racemized by the neuronal enzyme serine racemase (SR) from L-serine. We utilized constitutive SR knockout (SR

Indexed as

Craniocerebral TraumaNeocortexAnimalsFemaleGlutamic AcidInterneuronsMicePrefrontal CortexPregnancyGlutamic Acid

Identifiers

PMID37311798
PMCPMC10264435
OpenAlexW4380576775

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.