ArticleNature communications2023
Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- The vitamin D receptor story: discovery, control, and genomic reach.The Journal of endocrinology · 2026Review
- Maternal Vitamin D Deficiency During Pregnancy Alters Hepatic Metabolism in Adult Female Offspring Without Overt Metabolic Dysfunction.Metabolites · 2026Article
- Intergenerational effects of the microbiota on neurodevelopment: mechanisms and therapeutic perspectives.Acta pharmacologica Sinica · 2026Review
- Beyond bones, vitamin D as a sunshine hormone in type 2 diabetes mellitus and its complications.iScience · 2026Review
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues.Cell & bioscience · 2025Review
- Association of the uric acid-to-high-density lipoprotein cholesterol ratio with vitamin D deficiency in postmenopausal women: evidence from NHANES 2005-2016.Lipids in health and disease · 2025Article
- Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets.Signal transduction and targeted therapy · 2025Review
- Maternal Vitamin D Deficiency Is a Risk Factor for Infants' Epigenetic Gestational Age Acceleration at Birth in Japan: A Cohort Study.Nutrients · 2025Article
- Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesis.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Vitamin D and Aging: Central Role of Immunocompetence.Nutrients · 2024Review
- The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults.Frontiers in endocrinology · 2024Review
- Serum 25-hydroxy vitamin D level is associated with elastography-detected liver fibrosis in patients with type 2 diabetes mellitus in China.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
22 authors at 3 institutions in 2 countries.
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Abstract
Environmental factors may alter the fetal genome to cause metabolic diseases. It is unknown whether embryonic immune cell programming impacts the risk of type 2 diabetes in later life. We demonstrate that transplantation of fetal hematopoietic stem cells (HSCs) made vitamin D deficient in utero induce diabetes in vitamin D-sufficient mice. Vitamin D deficiency epigenetically suppresses Jarid2 expression and activates the Mef2/PGC1a pathway in HSCs, which persists in recipient bone marrow, resulting in adipose macrophage infiltration. These macrophages secrete miR106-5p, which promotes adipose insulin resistance by repressing PIK3 catalytic and regulatory subunits and down-regulating AKT signaling. Vitamin D-deficient monocytes from human cord blood have comparable Jarid2/Mef2/PGC1a expression changes and secrete miR-106b-5p, causing adipocyte insulin resistance. These findings suggest that vitamin D deficiency during development has epigenetic consequences impacting the systemic metabolic milieu.
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