Evidence map›Paper›PMID 37311454›Full record

ArticleCell2023

Cell protrusions and contractions generate long-range membrane tension propagation.

Henry De Belly, Shannon Yan, Hudson Borja da Rocha, Sacha Ichbiah, Jason P Town, Patrick J Zager, Dorothy C Estrada, Kirstin Meyer, Hervé Turlier, Carlos Bustamante and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
26.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 128 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026
    Review
  5. Article
  6. Caveolae mechanics in cellular functions and disease.Nature reviews. Molecular cell biology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Tension TRAAKer: a chemigenetic fluorescent membrane tension reporter.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Article
  14. Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Henry De BellyCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Shannon YanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA.
Hudson Borja da RochaCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, Inserm, Université PSL, Paris, France.
Sacha IchbiahCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, Inserm, Université PSL, Paris, France.
Jason P TownCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Patrick J ZagerCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Dorothy C EstradaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Kirstin MeyerCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Hervé TurlierCenter for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, Inserm, Université PSL, Paris, France. Electronic address: herve.turlier@college-de-france.fr.
Carlos BustamanteDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720, USA; Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, Berkeley, CA, USA; Department of Physics, University of California, Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA; Kavli Energy Nanoscience Institute, University of California, Berkeley, Berkeley, CA, USA. Electronic address: carlosjbustamante2@gmail.com.
Orion D WeinerCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: orion.weiner@ucsf.edu.
University of California, San Francisco · USCentre National de la Recherche Scientifique · FRQB3 · US

Funding

Cellular Decision Making Diversity SupplementR35GM118167 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orion D Weiner · 2016 to 2026
$10.3M
Integrative Program in Complex Biological System (ipCBS)T32EB009383 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARSHALL, WALLACE, WEINER, ORION D · 2009 to 2022
$3.2M
Molecular Biophysics Training GrantT32GM149436 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aashish Manglik · 2023 to 2026
$1.6M
Co-Translational Folding of Metamorphic Proteins: Assessing Structure-Function Transitions of the Mitotic Checkpoint Protein MAD2 on the Human Ribosome Surface and in the Presence of Folding EffectorsK99GM137074 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI YAN, SHANNON · 2020 to 2022
$278k
Biotechnology and Biological Sciences Research CouncilHoward Hughes Medical InstituteNIBIB NIH HHS T32 EB009383NIGMS NIH HHS K99 GM137074NIGMS NIH HHS R35 GM118167NIGMS NIH HHS T32 GM149436
6 · The paper itself

Abstract

Membrane tension is thought to be a long-range integrator of cell physiology. Membrane tension has been proposed to enable cell polarity during migration through front-back coordination and long-range protrusion competition. These roles necessitate effective tension transmission across the cell. However, conflicting observations have left the field divided as to whether cell membranes support or resist tension propagation. This discrepancy likely originates from the use of exogenous forces that may not accurately mimic endogenous forces. We overcome this complication by leveraging optogenetics to directly control localized actin-based protrusions or actomyosin contractions while simultaneously monitoring the propagation of membrane tension using dual-trap optical tweezers. Surprisingly, actin-driven protrusions and actomyosin contractions both elicit rapid global membrane tension propagation, whereas forces applied to cell membranes alone do not. We present a simple unifying mechanical model in which mechanical forces that engage the actin cortex drive rapid, robust membrane tension propagation through long-range membrane flows.

Indexed as

ActinsActomyosinActin CytoskeletonCell MembraneCell MovementActinsActomyosinactin cytoskeletonactomyosin contractilitycell cortexcell mechanicscell migrationcell polaritycell protrusionmembrane tensionoptical tweezersoptogenetics

Identifiers

PMID37311454
PMCPMC10330871
OpenAlexW4380369815

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.