Observational studyNeonatology2023
Assessment of Comfort during Less Invasive Surfactant Administration in Very Preterm Infants: A Multicenter Study.
Observational study in Neonatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- Can non-pharmacological comfort care replace fentanyl in LISA? The NONA-LISA feasibility study.Pediatric research · 2026Trial
- Cerebral Oxygen Saturation During Less-Invasive Surfactant Administration Using a High-Pressure CPAP Respiratory Support Delivery Room Protocol-A Cohort Study.Acta paediatrica (Oslo, Norway : 1992) · 2026Observational
- Pain Assessment During Less Invasive Surfactant Administration Using Skin Conductance: A Prospective Cohort Study.Pediatric research · 2026Observational
- International Multicenter Video Review on Neonatal Procedures: Lessons Learned from a Collaborative Study.Children (Basel, Switzerland) · 2026Article
- Dexmedetomidine for LISA procedure: a prospective observational single center experience.Italian journal of pediatrics · 2026Observational
- The effect of comprehensive developmental positioning program training on nurses' performance and infant comfort hospitalized in the neonatal intensive care unit.BMC medical education · 2025Article
- Dexmedetomidine for Less Invasive Surfactant Administration: Another Promising Medicine in an Ever-Growing Toolbox?Paediatric drugs · 2025Article
- Dexmedetomidine for Less Invasive Surfactant Administration: A Pilot Study.Paediatric drugs · 2025Article
- Procedural success and safety of a standardized less invasive surfactant administration protocol using fentanyl premedication and video laryngoscopy in preterm infants <32 weeks' gestation.Frontiers in pediatrics · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study was set up to investigate if and to what extent non-pharmacological analgesia is able to provide comfort to very preterm infants (VPI) during less invasive surfactant administration (LISA).
methodsThis was a prospective non-randomized multicenter observational study performed in level IV NICUs. Inborn VPI with a gestational age between 220/7 and 316/7 weeks, signs of respiratory distress syndrome, and the need for surfactant replacement were included. Non-pharmacological analgesia was performed in all infants during LISA. In case of failure of the first LISA attempt, additional analgosedation could be administered. COMFORTneo scores during LISA were assessed.
results113 VPI with a mean gestational age of 27 weeks (+/- 2.3 weeks) and mean birth weight of 946 g (+/- 33 g) were included. LISA was successful at the first laryngoscopy attempt in 81%. COMFORTneo scores were highest during laryngoscopy. At this time point, non-pharmacological analgesia provided adequate comfort in 61% of the infants. 74.4% of lower gestational aged infants (i.e., 220-266 weeks) were within the comfort zone during laryngoscopy compared to 51.6% of higher gestational aged infants (i.e., 270-320 weeks) (p = 0.016). The time point of surfactant administration did not influence the COMFORTneo scores during the LISA procedure.
conclusionNon-pharmacological analgesia provided comfort in as much as 61% of the included VPI during LISA. Further research is needed to both develop strategies to identify infants who, despite receiving non-pharmacological analgesia, are at high risk for experiencing discomfort during LISA and define patient-tailored dosage and choice of analgosedative drugs.
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