Evidence map›Paper›PMID 37311208›Full record

ArticleAmerican journal of respiratory and critical care medicine2023

Subphenotypes Assigned to Pediatric Acute Respiratory Failure Patients Show Differing Outcomes.

Heidi R Flori, Min Zhang, Jiaheng Xie, Guangyu Yang, Anil Sapru, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Martha A Q Curley, Mary K Dahmer

Registry-linked trialAbstract readLetter
In one paragraph

Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00814099 (Sedation Management in Pediatric Patients With Acute Respiratory Failure), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00814099 nacompletednot on this map

Sedation Management in Pediatric Patients With Acute Respiratory Failure

TypeinterventionalSponsorUniversity of PennsylvaniaRan2009 to 2013Enrolled2,449ConditionsRespiratory Insufficiency, Respiratory Distress Syndrome, Newborn, Lung DiseasesArmsTeam approach to sedation management, Usual approach to sedation management
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Distinct Blood and Lung Proteins Drive Pulmonary Capillary Leak in Children With Severe Hypoxemic Respiratory Failure.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2026
    Observational
  3. Article
  4. Article
  5. Parsimonious Electronic Health Record-Based Models to Assign Subphenotypes in Children With Acute Respiratory Distress Syndrome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
  6. Development and Validation of an Electronic Health Record-Based, Pediatric Acute Respiratory Distress Syndrome Subphenotype Classifier Model.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2024
    Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heidi R FloriDivision of Critical Care Medicine, Department of Pediatrics, and.
Min ZhangDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Jiaheng XieDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Guangyu YangInstitute of Statistics and Big Data, Renmin University of China, Beijing, China.ORCID 0000-0002-4692-1361
Anil SapruDepartment of Pediatrics, University of California, Los Angeles, Los Angeles, California.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, and.
Kevin L DelucchiDepartment of Psychiatry & Behavioral Sciences, University of California, San Francisco, San Francisco, California.
Pratik SinhaDepartment of Anesthesia, Washington University, St. Louis, Missouri.
Martha A Q CurleyDivision of Anesthesia and Critical Care Medicine (Perelman School of Medicine), Department of Family and Community Health (School of Nursing), University of Pennsylvania, Philadelphia, Pennsylvania; and.
Mary K DahmerDivision of Critical Care Medicine, Department of Pediatrics, and.

Funding

1/2 PROSpect: Prone and Oscillation Pediatric Clinical Trial (CCC)UH3HL141736 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHEIFETZ, IRA M, CURLEY, MARTHA AQ · 2019 to 2023
$7.9M
Precision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8M
ASCEND (ARDS in Children and ECMO initiation strategies impact on Neuro-Development)R01HL153519 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARBARO, RYAN PASQUALE · 2020 to 2024
$3.4M
Post-Intensive Care Syndrome Pediatrics, Longitudinal Cohort studyR01HD098269 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI CURLEY, MARTHA AQ, WATSON, R SCOTT · 2020 to 2024
$3.2M
ENdotypes in Children with Severe Acute Respiratory Distress SyNdrome: ImpAct on REsponse to Treatment (ENSNARE)R01HL149910 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAHMER, MARY K, FLORI, HEIDI R · 2020 to 2023
$2.9M
Precision Medicine in Sepsis with Critical IllnessR35GM142992 · NIGMS · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2021 to 2026
$2.4M
Microbiome and Nutrition in Severe PARDSR01HD104618 · NICHD · UNIVERSITY OF ARIZONA · PI Katri Vanamo Typpo · 2021 to 2026
$2.1M
Leveraging Biomarkers to Identify Subphenotypes in Children with Acute Respiratory Distress SyndromeR21HD097387 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAHMER, MARY K, FLORI, HEIDI R · 2019 to 2020
$459k
NHLBI NIH HHS R01 HL149910NHLBI NIH HHS R01 HL153519NHLBI NIH HHS R35 HL140026NHLBI NIH HHS UH3 HL141736NICHD NIH HHS R01 HD098269NICHD NIH HHS R01 HD104618NICHD NIH HHS R21 HD097387NIGMS NIH HHS R35 GM142992
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Respiratory Distress SyndromeRespiratory InsufficiencyBiomarkersChildHumansPhenotypeBiomarkers

Identifiers

PMID37311208
PMCPMC10395717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.