Evidence map›Paper›PMID 37310810›Full record

ArticleACS infectious diseases2023

MEPicides: α,β-unsaturated Fosmidomycin

Xu Wang, Rachel L Edwards, Haley S Ball, Kenneth M Heidel, Robert C Brothers, Claire Johnson, Amanda Haymond, Misgina Girma, Allyson Dailey, Jose Santinni Roma and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Apicoplast-Resident Processes: Exploiting the Chink in the Armour ofAdvances in pharmacological and pharmaceutical sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Xu WangDepartment of Chemistry, George Washington University, Washington, District of Columbia 20052, United States.ORCID 0000-0001-7379-5789
Rachel L EdwardsDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Haley S BallDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.ORCID 0000-0002-8840-3861
Kenneth M HeidelDepartment of Chemistry, George Washington University, Washington, District of Columbia 20052, United States.
Robert C BrothersDepartment of Chemistry, George Washington University, Washington, District of Columbia 20052, United States.
Claire JohnsonDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.
Amanda HaymondDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.
Misgina GirmaDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.
Allyson DaileyDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.
Jose Santinni RomaTuberculosis Research Section, LCIM, NIAID/NIH, Bethesda, Maryland 20892, United States.
Helena I BoshoffTuberculosis Research Section, LCIM, NIAID/NIH, Bethesda, Maryland 20892, United States.ORCID 0000-0002-4333-206X
Damon M OsbournDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.ORCID 0000-0002-4314-0391
Marvin J MeyersDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.
Robin D CouchDepartment of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.
Audrey R Odom JohnDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0001-8395-8537
Cynthia S DowdDepartment of Chemistry, George Washington University, Washington, District of Columbia 20052, United States.ORCID 0000-0001-5011-7029
George Mason University · USGeorge Washington University · USNational Institutes of Health · USSaint Louis University · USWashington University in St. Louis · US

Funding

MEP pathway resistance in Plasmodium falciparumR01AI103280 · NIAID · WASHINGTON UNIVERSITY · PI Audrey Ragan Odom John · 2013 to 2026
$5.5M
Structure-based microbially targeted prodrugsR01AI171514 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI DOWD, CYNTHIA SCHIECK, JEZ, JOSEPH MARTIN · 2022 to 2025
$4.0M
Inhibition of MEP pathway Isoprenoid BiosynthesisR01AI123433 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI DOWD, CYNTHIA SCHIECK, MEYERS, MARVIN J · 2016 to 2020
$2.6M
NIAID NIH HHS R01 AI103280NIAID NIH HHS R01 AI123433NIAID NIH HHS R01 AI171514
6 · The paper itself

Abstract

Malaria, a mosquito-borne disease caused by several parasites of the

Indexed as

AntimalarialsFosfomycinAnimalsChildHumansMicePentosephosphatesPlasmodium falciparumAntimalarialsFosfomycinfosmidomycinPentosephosphatesxylulose-5-phosphateantibioticantimalarialDXRMEP pathwayphosphonate prodrugPlasmodium falciparum

Identifiers

PMID37310810
PMCPMC10880585
OpenAlexW4380480415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.