Evidence map›Paper›PMID 37310750›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

The oncogenic function of PLAGL2 is mediated via ASCL2 and IGF2 and a Wnt-independent mechanism in colorectal cancer.

Anthony D Fischer, Daniel A Veronese Paniagua, Shriya Swaminathan, Hajime Kashima, Deborah C Rubin, Blair B Madison

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Bioinformatics Analysis IdentifiesDisease markers · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anthony D FischerDepartment of Genetics, Washington University School of Medicine, Saint Louis, Missouri, United States.ORCID 0000-0002-9521-3142
Daniel A Veronese PaniaguaWashington University School of Medicine, Saint Louis, Missouri, United States.
Shriya SwaminathanWashington University School of Medicine, Saint Louis, Missouri, United States.
Hajime KashimaDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States.
Deborah C RubinDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States.ORCID 0000-0002-4192-909X
Blair B MadisonDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, United States.ORCID 0000-0001-7457-1832
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Defining Mechanisms of Transformation Driven By the Zinc Finger Transcription Factor PLAGL2 in the Intestinal EpitheliumR01CA230289 · NCI · WASHINGTON UNIVERSITY · PI RUBIN, DEBORAH C. · 2019 to 2023
$1.8M
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA230289NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

Colorectal cancer (CRC) tumorigenesis and progression are linked to common oncogenic mutations, especially in the tumor suppressor

Indexed as

Colorectal NeoplasmsBasic Helix-Loop-Helix Proteinsbeta CateninCarcinogenesisCell Line, TumorCell ProliferationCell Transformation, NeoplasticDNA-Binding ProteinsGene Expression Regulation, NeoplasticHumansInsulin-Like Growth Factor IIRNA-Binding ProteinsTranscription FactorsWnt Signaling PathwayASCL2 protein, humanBasic Helix-Loop-Helix Proteinsbeta CateninDNA-Binding ProteinsIGF2 protein, humanInsulin-Like Growth Factor IIPLAGL2 protein, humanRNA-Binding ProteinsTranscription Factorscolorectal cancerIGF2PLAGL2tumorigenesisWnt

Identifiers

PMID37310750
PMCPMC10396286
OpenAlexW4380422475

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.