Evidence map›Paper›PMID 37310514›Full record

SynthesisInternational journal of colorectal disease2023

Association between inflammatory bowel disease and risk of incident prostate cancer: a systematic review and meta-analysis of cohort studies.

Ben-Gang Zhou, Qi Yu, Xin Jiang, Yu-Zhou Mei, Yan-Bing Ding, Mei Wang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ben-Gang Zhou *Dalian Medical University, Dalian, Liaoning Province, China.ORCID http://orcid.org/0000-0001-6096-3034
Qi Yu *Department of Gastroenterology, Wuxi Xinwu District Xinrui Hospital, Wuxi, Jiangsu Province, China.
Xin JiangDepartment of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hanjiang Middle Road, Hanjiang District, Yangzhou, Jiangsu Province, China.
Yu-Zhou MeiDepartment of Gastroenterology, The People's Hospital of China Three Gorges University, Yichang, Hubei Province, China.
Yan-Bing DingDepartment of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hanjiang Middle Road, Hanjiang District, Yangzhou, Jiangsu Province, China. ybding@yzu.edu.cn.ORCID http://orcid.org/0000-0002-0689-2199
Mei WangDepartment of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hanjiang Middle Road, Hanjiang District, Yangzhou, Jiangsu Province, China. yzuyanglin@163.com.
Northern Jiangsu People's Hospital · CNChina Three Gorges University · CNDalian Medical University · CNYangzhou University · CN

Funding

National Natural Science Foundation of China 82273084the Major Public Health Projects in Yangzhou: Screening projects of early gastrointestinal diseases 2018the Strengthening Health Care via Science and Education Project and Clinical Medical Innovation Platform Foundation of Yangzhou YXZX20184
6 · The paper itself

Abstract

BACKGROUND AND

objectiveNumerous observational studies have been conducted to investigate the potential association between inflammatory bowel disease (IBD) and prostate cancer (PCa). However, a definitive conclusion has yet to be established. We therefore performed a meta-analysis to explore the relationship between these two conditions.

methodsPubMed, Embase, and Web of Science databases were systematically searched to identify all relevant cohort studies that investigated the association between IBD and risk of incident PCa published from inception to February 2023. The pooled hazard ratios (HRs) with 95% confidence intervals (CI) was calculated as effect size for the outcome based on random-effects model meta-analysis.

resultsA total of 18 cohort studies with 592,853 participants were included. The meta-analysis revealed that IBD was linked to an elevated risk of incident PCa (HR = 1.20, 95% CI: 1.06-1.37, P = 0.004). Further subgroup analyses revealed that ulcerative colitis (UC) was linked to an increased risk of incident PCa (HR = 1.20, 95% CI: 1.06-1.38, P = 0.006), while Crohn's disease (CD) is not significantly associated with a higher risk of PCa (HR = 1.03, 95% CI: 0.91-1.17, P = 0.65). There was a significant correlation between IBD and an elevated risk of incident PCa in the European population, but such a correlation was not observed in the Asian and North American populations. Sensitivity analyses indicated that our results were robust.

conclusionsOur latest evidence indicates that IBD was linked to an elevated risk of incident PCa, especially in UC patients and the European population.

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesProstatic NeoplasmsCohort StudiesHumansMaleCrohn's diseaseInflammatory bowel diseaseMeta-analysisProstate cancerUlcerative colitis

Identifiers

PMID37310514
OpenAlexW4380422332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.