Evidence map›Paper›PMID 37310428›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Occipital hypometabolism is a risk factor for conversion to Parkinson's disease in isolated REM sleep behaviour disorder.

Giulia Carli, Sanne K Meles, Annette Janzen, Elisabeth Sittig, Rosalie V Kogan, Daniela Perani, Wolfgang H Oertel, Klaus L Leenders, REMPET Working Group

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  7. Article
  8. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Giulia CarliDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. g.carli@umcg.nl.ORCID 0000-0001-7216-2031
Sanne K MelesDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Annette JanzenDepartment of Neurology, Philipps-Universität Marburg, Marburg, Germany.
Elisabeth SittigDepartment of Neurology, Philipps-Universität Marburg, Marburg, Germany.
Rosalie V KoganDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Daniela PeraniSchool of Psychology, Vita-Salute San Raffaele University, Milan, Italy.
Wolfgang H OertelDepartment of Neurology, Philipps-Universität Marburg, Marburg, Germany.
Klaus L LeendersDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
REMPET Working Group
University Medical Center Groningen · NLPhilipps University of Marburg · DEVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIsolated REM sleep behaviour disorder (iRBD) patients are at high risk of developing clinical syndromes of the α-synuclein spectrum. Progression markers are needed to determine the neurodegenerative changes and to predict their conversion. Brain imaging with

methodsTwenty iRBD patients underwent two consecutive

resultsIndividual hypometabolism t-maps revealed three scenarios: (1) normal

conclusionsOur results suggest that occipital hypometabolism at baseline in iRBD implies a short-term conversion to PD. This might help in stratification strategies for disease-modifying trials.

Indexed as

Parkinson DiseaseREM Sleep Behavior Disorder3-IodobenzylguanidineFluorodeoxyglucose F18HumansIodine RadioisotopesPositron-Emission TomographyRisk FactorsTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane3-IodobenzylguanidineFluorodeoxyglucose F18Iodine-123Iodine RadioisotopesTropanes18F-FDG PETIsolated REM sleep behaviour disorderOccipital hypometabolismShort-term conversion

Identifiers

PMID37310428
PMCPMC10542098
OpenAlexW4380422070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.