Trial reportPsychological medicine2023
Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards.
Trial report in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Implicit opioid associations in OUD treatment: prediction of treatment response and moderation by mindfulness-oriented recovery enhancement.Psychological medicine · 2026Trial
- Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Development and Initial Validation of Mindfulness-Based Pain Reduction (MBPR) in Patients With Chronic Low Back Pain.Journal of pain research · 2025Trial
- Differential response of positive valence systems to psychotherapy for late-life depression: A pilot study.Journal of affective disorders · 2023Trial
- Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care: A Randomized Clinical Trial.JAMA internal medicine · 2022Trial
- Not Feeling It: Modifiable Correlates of Anhedonia.Behavioral sciences (Basel, Switzerland) · 2026Article
- Positive Emotion Regulation in Addiction: A New Frontier for Recovery Science.Current addiction reports · 2026Review
- Anhedonia: Current and future treatments.PCN reports : psychiatry and clinical neurosciences · 2025Review
- Contemporaneous Link Between Pain and Craving in Patients Recovering from Prescription Opioid Use Disorder During Residential Treatment.Substance use & misuse · 2025Article
- Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder.Annals of medicine · 2024Article
- Virtual reality-based Mindfulness-Oriented Recovery Enhancement (MORE-VR) as an adjunct to medications for opioid use disorder: a Phase 1 trial.Annals of medicine · 2024Article
- Blunted sensitivity to expected value during risky decision making in individuals with problematic pornography use.Journal of behavioral addictions · 2024Article
- A smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial.Contemporary clinical trials communications · 2024Article
- Behavioral therapies targeting reward mechanisms in substance use disorders.Pharmacology, biochemistry, and behavior · 2024Review
- Happy Hour: The association between trait hedonic capacity and motivation to drink alcohol.Addictive behaviors reports · 2024Article
- Association of Cortico-Striatal Engagement During Cue Reactivity, Reappraisal, and Savoring of Drug and Non-Drug Stimuli With Craving in Heroin Addiction.The American journal of psychiatry · 2024Article
- Development of two novel treatments to promote smoking cessation: Savor and retrieval-extinction training pilot clinical trial findings.Experimental and clinical psychopharmacology · 2024Article
- Changes in peripheral oxytocin and vasopressin during a silent month-long Insight meditation retreat.Frontiers in endocrinology · 2024Article
- Restructuring reward: A pilot study to enhance natural reward response in adults with cannabis use disorder.Drug and alcohol dependence · 2023Article
- Prefrontal cortical response to natural rewards and self-reported anhedonia are associated with greater craving among recently withdrawn patients in residential treatment for opioid use disorder.Brain research bulletin · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNeuropsychopharmacologic effects of long-term opioid therapy (LTOT) in the context of chronic pain may result in subjective anhedonia coupled with decreased attention to natural rewards. Yet, there are no known efficacious treatments for anhedonia and reward deficits associated with chronic opioid use. Mindfulness-Oriented Recovery Enhancement (MORE), a novel behavioral intervention combining training in mindfulness with savoring of natural rewards, may hold promise for treating anhedonia in LTOT.
methodsVeterans receiving LTOT (
resultsPatients treated with MORE demonstrated significantly increased LPP and SCL to natural reward cues and greater decreases in subjective anhedonia relative to those in the SG. The effect of MORE on reducing anhedonia was statistically mediated by increases in LPP response during savoring.
conclusionsMORE enhances motivated attention to natural reward cues among chronic pain patients on LTOT, as evidenced by increased electrocortical and sympathetic nervous system responses. Given neurophysiological evidence of clinical target engagement, MORE may be an efficacious treatment for anhedonia among chronic opioid users, people with chronic pain, and those at risk for opioid use disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.