ArticlePsychological medicine2023
Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Post-traumatic stress disorder among LGBTQ people: a systematic review and meta-analysis.Epidemiology and psychiatric sciences · 2023Pooled it
- Genetic risk for schizophrenia modulates WIN 55,212-2 reward: Evidence from a heterozygous transmembrane domain neuregulin 1 mutant mouse model.Psychopharmacology · 2026Article
- Interaction between Neighborhood Exposome and Genetic Risk in Child Persistent Distressing Psychotic-like Experiences.Nature. Mental health · 2026Article
- Investigating the polygenic relationship between heavy cannabis use and schizophrenia in the All of Us Research Program.Psychological medicine · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Association of Polygenic Risk Scores for Schizophrenia with Psychosis-Proneness Indicators in the General Population: A Narrative Review.Consortium psychiatricum · 2025Review
- Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults.Translational psychiatry · 2022Article
- A network approach to relationships between cannabis use characteristics and psychopathology in the general population.Scientific reports · 2022Article
- Cannabis and Psychosis: Weeding Out Fact from Fiction.Missouri medicineArticle
Corrections and comments
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Authors and funding
29 authors at 17 institutions in 9 countries.
Funding
Abstract
backgroundIt has not yet been determined if the commonly reported cannabis-psychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders.
methodsWe examined whether the relationship between polygenic risk score for schizophrenia (PRS-Sz) and psychotic-like experiences (PLEs), as measured by the Community Assessment of Psychic Experiences-42 (CAPE-42) questionnaire, is mediated or moderated by lifetime cannabis use at 16 years of age in 1740 of the individuals of the European IMAGEN cohort. Secondary analysis examined the relationships between lifetime cannabis use, PRS-Sz and the various sub-scales of the CAPE-42. Sensitivity analyses including covariates, including a PRS for cannabis use, were conducted and results were replicated using data from 1223 individuals in the Dutch Utrecht cannabis cohort.
resultsPRS-Sz significantly predicted cannabis use (
conclusionsThese results suggest that cannabis use remains a risk factor for PLEs, over and above genetic vulnerability for schizophrenia. This research does not support the notion that the cannabis-psychosis link is limited to individuals who are genetically predisposed to psychosis and suggests a need for research focusing on cannabis-related processes in psychosis that cannot be explained by genetic vulnerability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.