Evidence map›Paper›PMID 37310328›Full record

Trial reportPsychological medicine2023

Disentangling the links between gastric emptying and binge eating

Pamela K Keel, Lisa A Eckel, Britny A Hildebrandt, Alissa A Haedt-Matt, Daryl J Murry, Jonathan Appelbaum, David C Jimerson

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Piezo1 in Digestive System Function and Dysfunction.International journal of molecular sciences · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Pamela K KeelDepartment of Psychology, Florida State University, Tallahassee, FL, USA.ORCID 0000-0001-6542-5147
Lisa A EckelDepartment of Psychology and Neuroscience Program, Florida State University, Tallahassee, FL, USA.
Britny A HildebrandtDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Alissa A Haedt-MattDepartment of Psychology, Illinois Institute of Technology, Chicago, IL, USA.
Daryl J MurryCollege of Pharmacy, University of Nebraska Medical Center, Omaha, NE, USA.
Jonathan AppelbaumCollege of Medicine, Florida State University, Tallahassee, FL, USA.
David C JimersonDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Florida State University · USBeth Israel Deaconess Medical Center · USIllinois Institute of Technology · USUniversity of Nebraska Medical Center · USUniversity of Pittsburgh · US

Funding

UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
Biobehavioral Prediction of Illness Trajectory in Bulimic SyndromesR01MH111263 · NIMH · FLORIDA STATE UNIVERSITY · PI KEEL, PAMELA K. · 2016 to 2020
$2.1M
NIH HHS UL1RR024979NIMH NIH HHS R01MH111263
6 · The paper itself

Abstract

backgroundPrior work supports delayed gastric emptying in anorexia nervosa and bulimia nervosa (BN) but not binge-eating disorder, suggesting that neither low body weight nor binge eating fully accounts for slowed gastric motility. Specifying a link between delayed gastric emptying and self-induced vomiting could offer new insights into the pathophysiology of purging disorder (PD).

methodsWomen (

resultsDelayed gastric emptying was associated with purging with no main or moderating effects of binge eating in the placebo condition. Medication eliminated group differences in gastric emptying but did not alter group differences in reported gastrointestinal distress. Exploratory analyses revealed that medication caused increased postprandial PYY release, which predicted elevated gastrointestinal distress.

conclusionsDelayed gastric emptying demonstrates a specific association with purging behaviors. However, correcting disruptions in gastric emptying may exacerbate disruptions in gut peptide responses specifically linked to the presence of purging after normal amounts of food.

Indexed as

Binge-Eating DisorderBulimiaFeeding and Eating DisordersGastroparesisCase-Control StudiesFemaleGastric EmptyingHumansbinge eatingBulimia Nervosagastric emptyingmedicationPurging disorder

Identifiers

PMID37310328
PMCPMC10106287
OpenAlexW3198005760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.