ArticlePsychological medicine2023
Brain signatures in children who contemplate suicide: learning from the large-scale ABCD study.
Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Self-injurious thoughts and behaviors and alterations in positive valence systems: A systematic review of the literature.Journal of psychiatric research · 2022Pooled it
- The Predictive Value of Preadolescent Suicidal Ideation Reporter Discrepancies in the ABCD Study.Child psychiatry and human development · 2026Article
- Differential neural activation during reward processing in preadolescent suicidal ideation.Child psychiatry and human development · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Examining Causal Pathways to Suicidal Ideation and Nonsuicidal Self-Injury in the Adolescent Brain Cognitive Development Study.Suicide & life-threatening behavior · 2025Article
- Adolescent suicide behaviors associate with accelerated reductions in cortical gray matter volume and slower decay of behavioral activation Fun-Seeking scores.Scientific reports · 2025Article
- A multi-level examination of impulsivity and links to suicide ideation among Native American youth.Journal of affective disorders · 2024Article
- Aberrant connectivity in the right amygdala and right middle temporal gyrus before and after a suicide attempt: Examining markers of suicide risk.Journal of affective disorders · 2023Article
- Sex and age variations in the impact of puberty on cortical thickness and associations with internalizing symptoms and suicidal ideation in early adolescence.Developmental cognitive neuroscience · 2023Article
- Depression, Non-Suicidal Self-Injury, and Suicidality in Adolescents: Common and Distinct Precursors, Correlates, and Outcomes.Journal of psychiatry and brain science · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundSuicide is the second-leading cause of death in youth. Understanding the neural correlates of suicide ideation (SI) in children is crucial to ongoing efforts to understand and prevent youth suicide. This study characterized key neural networks during rest and emotion task conditions in an epidemiologically informed sample of children who report current, past, or no SI.
methodsData are from the adolescent brain cognitive development study, including 8248 children (ages 9-10; mean age = 119.2 months; 49.2% female) recruited from the community. Resting-state functional connectivity (RSFC) and activation to emotional stimuli in the salience (SN) and default mode (DMN) networks were measured through fMRI. Self-reported SI and clinical profiles were gathered. We examined the replicability of our model results through repeated sub-sample reliability analyses.
resultsChildren with current SI (2.0%), compared to those without any past SI, showed lower DMN RSFC (
conclusionsResults from a large brain imaging study using robust statistical approaches suggest aberrant DMN functioning in children with current suicide ideation. Findings suggest potential mechanisms that may be targeted in suicide prevention efforts.
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